Substantial research has been undertaken to understand the relationship between spelling and sound, but we know little about the relationship between spelling and meaning in alphabetic writing systems. We present a computational analysis of English writing in which we develop new constructs to describe this relationship. Diagnosticity captures the amount of meaningful information in a given spelling, whereas specificity estimates the degree of dispersion of this meaning across different spellings for a particular sound sequence. Using these two constructs, we demonstrate that particular suffix spellings tend to be reserved for particular meaningful functions. We then show across three paradigms (nonword classification, spelling, and eye tracking during sentence reading) that this form of regularity between spelling and meaning influences the behaviour of skilled readers, and that the degree of this behavioural sensitivity mirrors the strength of spelling-to-meaning regularities in the writing system. We close by arguing that English spelling may have become fractionated such that the high degree of spelling-sound inconsistency maximises the transmission of meaningful information.
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http://dx.doi.org/10.1016/j.cognition.2018.09.013 | DOI Listing |
Mult Scler
January 2025
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Testing for myelin oligodendrocyte glycoprotein immunoglobulin G antibodies (MOG-IgG) is essential to the diagnosis of MOG antibody-associated disease (MOGAD). Due to its central role in the evaluation of suspected inflammatory demyelinating disease, the last 5 years has been marked by an abundance of research into MOG-IgG testing ranging from appropriate patient selection, to assay performance, to utility of serum titers as well as cerebrospinal fluid (CSF) testing. In this review, we synthesize current knowledge pertaining to the "who, what, where, when, why, and how" of MOG-IgG testing, with the aim of facilitating accurate MOGAD diagnosis in clinical practice.
View Article and Find Full Text PDFPharmaceutics
January 2025
Innovation and Medical Science, SIFI S.p.A., 95025 Aci Sant'Antonio, Italy.
Retinal ganglion cell (RGC) protection represents an unmet need in glaucoma. This study assessed the neuroprotective, antioxidant, and anti-inflammatory effect of a new nutraceutical formulation named Epicolin, based on citicoline, homotaurine, epigallocatechin-3-gallate, forskolin, and vitamins, through in vitro and in vivo studies. The neuroprotective effect of Epicolin or its single components, and Epicolin compared to an untreated control and two marketed formulations [Formulation G (FG) and N (FN)], was evaluated in neuroblastoma cells (SH-SY5Y) challenged with staurosporine.
View Article and Find Full Text PDFPharmaceutics
December 2024
Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia.
Background/objectives: Selective laser sintering (SLS) is one of the most promising 3D printing techniques for pharmaceutical applications as it offers numerous advantages, such as suitability to work with already approved pharmaceutical excipients, the elimination of solvents, and the ability to produce fast-dissolving, porous dosage forms with high drug loading. When the powder mixture is exposed to elevated temperatures during SLS printing, the active ingredients can be converted from the crystalline to the amorphous state, which can be used as a strategy to improve the dissolution rate and bioavailability of poorly soluble drugs. This study investigates the potential application of SLS 3D printing for the fabrication of tablets containing the poorly soluble drug carvedilol with the aim of improving the dissolution rate of the drug by forming an amorphous form through the printing process.
View Article and Find Full Text PDFPolymers (Basel)
January 2025
State Key Laboratory of Material Processing and Die & Mold Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
Biological surfaces with physical discontinuity or chemical heterogeneity possess special wettability in the form of anisotropic wetting behavior. However, there are several challenges in designing and manufacturing samples with anisotropic wettability. This study investigates the fabrication of PTFE/PDMS grid membranes using Direct Ink Writing (DIW) 3D printing for oil-water separation applications.
View Article and Find Full Text PDFJ Clin Med
January 2025
Department of Medical Specialties I, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.
Purpose: is the main etiologic agent implicated in primary amoebic meningoencephalitis (PAM). It is also known as the brain-eating amoeba because of the severe brain inflammation following infection, with a survival rate of about 5%. This review aims to identify infections and evaluate patients' progression.
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