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Noninvasive detection of twin zygosity using genome-wide linkage disequilibrium information.
Clin Transl Med
December 2024
Department of Obstetrics, Center of Fetal Medicine & intrauterine pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Dear Editor, in this study, we propose a novel linkage disequilibrium information-based noninvasive zygosity (LDNZ) assessment method in twin pregnancies. It combines fetus-specific allele frequency analysis with LD block to reduce the number of required single nucleotide polymorphism markers and experiment costs. LDNZ method offers a noninvasive, accurate, and cost-effective solution for zygosity assessment, addressing the need for precise obstetric care in twin pregnancies.
View Article and Find Full Text PDFMacrophage Therapy for Acute Liver Injury (MAIL): a study protocol for a phase 1 randomised, open-label, dose-escalation study to evaluate safety, tolerability and activity of allogeneic alternatively activated macrophages in patients with paracetamol-induced acute liver injury in the UK.
BMJ Open
December 2024
Centre for Cardiovascular Science, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, UK
Introduction: Acute liver failure (ALF) has no effective treatment other than liver transplantation and is commonly caused by paracetamol overdose. New treatments are needed to treat and prevent ALF. Alternatively-activated macrophages (AAMs) can promote resolution of liver necrosis and stimulate hepatocyte proliferation.
View Article and Find Full Text PDFThe 100 most impactful articles in foot and ankle surgery: An altmetric analysis.
J Foot Ankle Surg
December 2024
Department of Orthopaedic Surgery, University of Alabama at Birmingham; Birmingham, AL, 1201 11th Ave S, Birmingham, AL 35205, United States. Electronic address:
Citation count and impact factor of the publishing journal are two historically utilized metrics to determine an article's impact in its research field. However, these metrics are limited given the rise in research dissemination through social media. Across other orthopedic specialties, the Altmetric Attention Score (AAS) has been used to determine which articles are most impactful.
View Article and Find Full Text PDFBroad range lipidomics and metabolomics coupled with 16S rRNA sequencing to reveal the mechanisms of Huangkui Capsule against cisplatin-induced nephrotoxicity.
J Ethnopharmacol
December 2024
Department of Clinical Pharmacology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, No. 155 Hanzhong Road, Nanjing, 210029, China. Electronic address:
Article Synopsis
- Huangkui Capsule (HKC), a traditional Chinese medicine, has shown promise in protecting kidneys from cisplatin-induced nephrotoxicity (CIN), which is a major limitation of cisplatin use in cancer treatment.
- A study conducted on rats revealed that HKC significantly reduced kidney damage indicators and improved metabolic profiles, while also affecting gut microbiota diversity.
- Further analysis indicated a correlation between certain gut bacteria and metabolic changes, suggesting that HKC's protective effects may rely on its interaction with the gut microbiome.
OZOILE: evaluating its impact and future applications in inflammatory dermatological treatments.
Eur J Transl Myol
December 2024
Unit of Pediatric Surgery, Department of Human Pathology of Adult and Childhood "Gaetano Barresi", University of Messina, Messina.
Dear Editor, I would like to express my sincere appreciation for the publication and detailed discussion of therapies for dermatological and inflammatory conditions, as exemplified in the recent article "Onychocryptosis: a retrospective study of clinical aspects, inflammation treatment, and pain management using Ozoile as a hydrogel and cream formulation" by Vincenzo Francavilla et al. This insightful study has provided a comprehensive overview of the management of onychocryptosis, a common and often distressing condition, and has highlighted the innovative use of OZOILE® in a clinical setting.1 [.
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