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Delayed feeding disrupts diurnal oscillations in the gut microbiome of a neotropical bat in captivity.
FEMS Microbiol Ecol
January 2025
School of Science, Engineering and Environment, Salford University, Manchester, UK.
Diurnal rhythms of the gut microbiota are emerging as an important yet often overlooked facet of microbial ecology. Feeding is thought to stimulate gut microbial rhythmicity, but this has not been explicitly tested. Moreover, the role of the gut environment is entirely unexplored, with rhythmic changes to gut pH rather than feeding per se possibly affecting gut microbial fluctuations.
View Article and Find Full Text PDFTriple-negative breast cancer modifies the systemic immune landscape and alters neutrophil functionality.
NPJ Breast Cancer
January 2025
Division of Tumor Biology & Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Cancer disrupts intratumoral innate-adaptive immune crosstalk, but how the systemic immune landscape evolves during breast cancer progression remains unclear. We profiled circulating immune cells in stage I-III and stage IV triple-negative breast cancer (TNBC) patients and healthy donors (HDs). Metastatic TNBC (mTNBC) patients had reduced T cells, dendritic cells, and differentiated B cells compared to non-metastatic TNBC patients and HDs, partly linked to prior chemotherapy.
View Article and Find Full Text PDFDisruption of midgut homeostasis by microplastics in Spodoptera frugiperda: Insights into inflammatory and oxidative mechanisms.
J Hazard Mater
January 2025
Engineering Research Center of Biocontrol, Ministry of Education Guangdong Province, South China Agricultural University, Guangzhou 510640, China. Electronic address:
Microplastics have evolved as widespread contaminants in terrestrial and aquatic environments, raising significant environmental concerns due to their persistence and bioaccumulation. In this study, we investigated the toxicity of polyethylene microplastics (PE-MPs) on the agricultural insect, Spodoptera frugiperda. Maize leaves containing three sizes (0.
View Article and Find Full Text PDFCurrent understanding of human bioaccumulation patterns and health effects of exposure to perfluorooctane sulfonate (PFOS).
J Hazard Mater
January 2025
Fisheries Science Institute, Chonnam National University, Yeosu 59626, South Korea; Department of Ocean Integrated Science, Chonnam National University, Yeosu 59626, South Korea. Electronic address:
Perfluorooctane sulfonate (PFOS) is a persistent organic pollutant of global concern due to its environmental presence,bioaccumulative potential and toxicological impacts. This review synthesizes current knowledge regarding PFOS exposure, bioaccumulation patterns and adverse health outcomes in human population. Analysis of worldwide biomonitoring data, and epidemiological studies reveals PFOS systemic effects, including immunological dysfunction (decreased vaccine response), developmental toxicity (reduced birth weight), hepatic metabolic disruption, potential carcinogenogenicity, and reproductive abnormalities.
View Article and Find Full Text PDFNovel clinical trial designs emerging from the molecular reclassification of cancer.
CA Cancer J Clin
January 2025
Medical College of Wisconsin Cancer Center, Milwaukee, Wisconsin, USA.
Next-generation sequencing has revealed the disruptive reality that advanced/metastatic cancers have complex and individually distinct genomic landscapes, necessitating a rethinking of treatment strategies and clinical trial designs. Indeed, the molecular reclassification of cancer suggests that it is the molecular underpinnings of the disease, rather than the tissue of origin, that mostly drives outcomes. Consequently, oncology clinical trials have evolved from standard phase 1, 2, and 3 tissue-specific studies; to tissue-specific, biomarker-driven trials; to tissue-agnostic trials untethered from histology (all drug-centered designs); and, ultimately, to patient-centered, N-of-1 precision medicine studies in which each patient receives a personalized, biomarker-matched therapy/combination of drugs.
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