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http://dx.doi.org/10.1016/S1474-4422(18)30401-0 | DOI Listing |
Discov Oncol
September 2024
Department of Encephalopathy, Zhoukou Hospital of Traditional Chinese Medicine, Zhoukou, 466099, China.
Background: Recent studies have identified the presence of cancer-associated fibroblasts (CAFs) within glioblastoma (GBM), yet their biological roles and underlying mechanisms remain poorly understood. This study aimed to construct a CAF-related prognostic model to guide patient prognosis and treatment strategies.
Method: We employed various bioinformatics methods, including enrichment analysis, Weighted Gene Co-expression Network Analysis (WGCNA), Lasso regression analysis, and machine learning techniques such as XGBoost and Random Forest, to develop a novel risk index termed CAFscore.
EMBO Rep
August 2024
Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-8505, USA.
Signals emanating from the T-cell receptor (TCR), co-stimulatory receptors, and cytokine receptors each influence CD8 T-cell fate. Understanding how these signals respond to homeostatic and microenvironmental cues can reveal new ways to therapeutically direct T-cell function. Through forward genetic screening in mice, we discover that loss-of-function mutations in LDL receptor-related protein 10 (Lrp10) cause naive and central memory CD8 T cells to accumulate in peripheral lymphoid organs.
View Article and Find Full Text PDFParkinsonism Relat Disord
June 2024
Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy; Highly Specialized Laboratory, ASST Spedali Civili of Brescia, Brescia, Italy. Electronic address:
Stem Cell Res
June 2024
The Institute for Tissue Engineering and Regenerative Medicine/Key Laboratory of Health Commission of Shandong Province, Liaocheng. University/Liaocheng People's Hospital, Liaocheng, Shandong 252000, China; Affiliated Yidu Central Hospital, Weifang Medical University, Weifang, Shandong 262600, China; Zhengzhou Revogene Biotechnology Inc. Zhengzhou, Henan 450002, China. Electronic address:
Cell Mol Life Sci
February 2024
Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands.
Autosomal dominant variants in LRP10 have been identified in patients with Lewy body diseases (LBDs), including Parkinson's disease (PD), Parkinson's disease-dementia (PDD), and dementia with Lewy bodies (DLB). Nevertheless, there is little mechanistic insight into the role of LRP10 in disease pathogenesis. In the brains of control individuals, LRP10 is typically expressed in non-neuronal cells like astrocytes and neurovasculature, but in idiopathic and genetic cases of PD, PDD, and DLB, it is also present in α-synuclein-positive neuronal Lewy bodies.
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