Aim: Procaine that is able to reach the peripheral nervous system (PNS) was conjugated as a ligand with lipid nanovesicle and loaded with ribavirin (a broad spectrum antiviral drug incapable of entering the PNS on its own) to target the PNS with a dual-drug effect.
Materials & Methods: Different physicochemical characterizations, γ-scintigraphy and electromyography of the developed nanovesicle were conducted.
Results: Marked capability of the optimized radiolabeled formulation to target PNS was observed in rats. Electromyography signals were reduced after treatment with the formulation on conscious rats.
Conclusion: The developed nanocarrier can deliver drug successfully at the PNS and reduce excitation of the nerve and thus give a better therapeutic option for treatment of various diseases and disorders of the PNS.
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| http://dx.doi.org/10.2217/nnm-2018-0192 | DOI Listing |
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