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Multifaceted Roles of MeCP2 in Cellular Regulation and Phase Separation: Implications for Neurodevelopmental Disorders, Depression, and Oxidative Stress.
Biochem Cell Biol
January 2025
University of Victoria Faculty of Science, Biochemsitry and Microbiology, Victoria, British Columbia, Canada;
Methyl CpG binding protein 2 (MeCP2) is a chromatin-associated protein that remains enigmatic despite more than 30 years of research, primarily due to the ever-growing list of its molecular functions, and, consequently, its related pathologies. Loss of function MECP2 mutations cause the neurodevelopmental disorder Rett syndrome (RTT); in addition, dysregulation of MeCP2 expression and/or function are involved in numerous other pathologies, but the mechanisms of MeCP2 regulation are unclear. Advancing technologies and burgeoning mechanistic theories assist our understanding of the complexity of MeCP2 but may inadvertently cloud it if not rigorously tested.
View Article and Find Full Text PDFGlioblastoma, IDH-wildtype manifesting as intracranial hemorrhage: A case report highlighting the clinical utility of digital polymerase chain reaction in integrated diagnoses.
Neuropathology
January 2025
Department of Pathology, Kyorin University Faculty of Medicine, Tokyo, Japan.
The manifestation of glioblastoma, IDH-wildtype (GB) as intracranial hemorrhage (ICH) presents diagnostic and therapeutic challenges. Molecular characteristics, including TERT promoter mutation, EGFR amplification, and chromosome 7 gain/10 loss, were incorporated to diagnose GB in the fifth edition of the World Health Organization Classification of Tumors of the Central Nervous System. When molecular analyses fail to detect low fractions of these genetic alterations, the integrated diagnosis of GB can be enigmatic.
View Article and Find Full Text PDFUnearthing the secrets of Australia's most enigmatic and cryptic mammal, the marsupial mole.
Sci Adv
January 2025
School of BioSciences, The University of Melbourne, Parkville, Victoria 3010, Australia.
The marsupial moles are arguably Australia's most enigmatic marsupials. Almost indistinguishable from placental (eutherian) moles, they provide a striking example of convergent evolution. Exploring the genome of the southern marsupial mole, we provide insights into its unusual biology.
View Article and Find Full Text PDFUncovering the mechanisms underlying the efficacy of probiotic strains in mitigating food allergies: an emphasis on gut microbiota and indoleacrylic acid.
Front Nutr
December 2024
Children's ENT Department, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Wuxi, China.
Food allergies manifest as systemic or digestive allergic responses induced by food allergens, and their progression has been demonstrated to be intimately associated with the host's gut microbiota. Our preceding investigation has revealed that the probiotic strains CCFM1189 and CCFM1190 possess the capability to mitigate the symptoms of food allergy in mice. However, the underlying mechanisms and material foundations through which these probiotic strains exert their effects remain enigmatic.
View Article and Find Full Text PDFThe early Cambrian is a non-feeding larva of a scalidophoran worm.
Proc Biol Sci
December 2024
Université de Lyon, Université Claude Bernard Lyon 1, ENS Lyon, CNRS UMR 5276, Laboratoire de géologie de Lyon: Terre, Planètes, Environnement, Bâtiment GEODE, Villeurbanne 69622, France.
With its bag-like appearance, spiny ornament and single opening, is one of the most enigmatic animals of the early Cambrian Kuanchuanpu Formation ( 535 Ma) and has been at the heart of debates concerning the origin of two major animal lineages: the deuterostomes and the ecdysozoans. Although Ecdysozoa is now the most plausible option, key aspects of its palaeobiology have remained elusive. I suggest here that was the possible larval stage of one of the numerous scalidophoran worms that co-existed with it in the Kuanchuanpu biota, especially those with bilateral pairs of broad-based sclerites such as .
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