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Oxidative NHC catalysis: direct activation of β sp carbons of saturated acid chlorides. | LitMetric
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Oxidative NHC catalysis: direct activation of β sp carbons of saturated acid chlorides.

Shi-Ya Zhu Hua Zhang Qing-Wei Ma Dou Liu Xin-Ping Hui

Chem Commun (Camb)

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China.

Published: January 2019

The first activation of saturated acid chlorides by oxidative N-heterocyclic carbene catalysis has been successfully utilized to synthesize enantio-enriched spirooxindole lactones and δ-lactones. The reaction involves the transformation of the β sp3 carbon of saturated acid chlorides into an electrophilic carbon as a key step. The product was obtained in excellent yield and stereoselectivity.

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 Source
http://dx.doi.org/10.1039/c8cc08578aDOI Listing

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