AI Article Synopsis
- Nitric oxide (NO) donor drugs have various clinical uses and are being explored for treating multiple diseases.
- The article discusses the creation of a new nanoparticle that releases NO, made by encapsulating the NO donor tDodSNO in a styrene and maleic acid co-polymer.
- The pharmacological effects of this nanoparticle, called SMA-tDodSNO, are detailed in a related study focusing on its potential for targeted vasodilation and addressing vascular hyperpermeability.
Article Abstract
Nitric oxide (NO) donor drugs have a range of clinical applications, and are also being developed as therapeutics for the potential treatment of multiple diseases. This article presents data describing the synthesis and characterisation of a novel NO releasing nanoparticle formed by encapsulation of the NO donor tDodSNO into a co-polymer of styrene and maleic acid (SMA) to afford SMA-tDodSNO. The pharmacological activity of SMA-tDodSNO is discussed in our accompanying manuscript "Encapsulation of tDodSNO generates a photoactivated nitric oxide releasing nanoparticle for localized control of vasodilation and vascular hyperpermeability". (Alimoradio et al. [1]).
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249518 | PMC |
| http://dx.doi.org/10.1016/j.dib.2018.10.149 | DOI Listing |
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