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CT Perfusion Metrics as Indicators of Intracranial Atherosclerotic Stenosis in Acute Ischemic Stroke: A Clinical Analysis.
Curr Neurovasc Res
December 2024
Department of Neurosurgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Article Synopsis
- Intracranial Atherosclerotic Stenosis (ICAS) is a major cause of acute ischemic stroke, and the study investigates how Computed Tomography Perfusion (CTP) can help diagnose and manage it in patients.
- A retrospective analysis of 224 acute ischemic stroke patients showed that CTP can differentiate ICAS from other stroke causes through specific perfusion parameters, indicating ICAS patients have more salvageable brain tissue.
- Results suggest that CTP not only improves diagnostic accuracy (with an AUC of 0.7779) but also correlates with better functional outcomes, highlighting its potential role in treatment decisions for ICAS-induced strokes.
Limb salvage prediction in peripheral artery disease patients using angiographic computer vision.
Vascular
January 2025
Department of Vascular Surgery, University Hospital Leipzig, Leipzig, Germany.
Background: Peripheral artery disease (PAD) outcomes often rely on the expertise of individual vascular units, introducing potential subjectivity into disease staging. This retrospective, multicenter cohort study aimed to demonstrate the ability of artificial intelligence (AI) to provide disease staging based on inter-institutional expertise by predicting limb outcomes in post-interventional pedal angiograms of PAD patients, specifically in comparison to the inframalleolar modifier in the Global Limb Anatomic Staging System (IM GLASS).
Methods: We used computer vision (CV) based on the MobileNetV2 model, implemented via TensorFlow.
Decoding the general role of tRNA queuosine modification in eukaryotes.
Sci Rep
January 2025
Department of Molecular Evolution, Centro de Astrobiología (CAB), CSIC-INTA, Carretera de Ajalvir Km 4, Torrejón de Ardoz, 28850, Madrid, Spain.
Transfer RNA (tRNA) contains modified nucleosides essential for modulating protein translation. One of these modifications is queuosine (Q), which affects NAU codons translation rate. For decades, multiple studies have reported a wide variety of species-specific Q-related phenotypes in different eukaryotes, hindering the identification of a general underlying mechanism behind that phenotypic diversity.
View Article and Find Full Text PDF[Current advances in the analysis of free RNA modified nucleosides by high performance liquid chromatography-tandem mass spectrometry].
Se Pu
January 2025
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;3. University of Chinese Academy of Sciences, Beijing 100049, China.
Post-transcriptional ribonucleic acid (RNA) modifications play crucial roles in regulating gene expression, with both eukaryotic and prokaryotic RNA exhibiting more than 170 distinct and ubiquitous modifications. RNA turnover generates numerous free nucleosides, including unmodified nucleosides and a variety of modified ones. Unlike unmodified nucleosides, modified nucleosides are not further degraded or used in the salvage-synthesis pathway owing to a lack of specific enzymes, which leads to the cytosolic accumulation or cellular efflux of modified nucleosides.
View Article and Find Full Text PDFAnterior Arthroscopic Approach for Multidirectional Shoulder Instability: Posterior Bone Block, Dynamic Anterior Stabilization, and Modified McLaughlin.
Arthrosc Tech
November 2024
Department of Orthopedic Surgery and Traumatology, Olympia, Quirón Salud, Madrid, Spain.
Multidirectional shoulder instability represents an ongoing challenge for orthopaedic surgeons, and multiple techniques have been described to treat this condition. Posterior glenoid dysplasia is a known risk factor for posterior instability as well as persistent or recurrent instability following posterior stabilization procedures. Recurrent shoulder instability complicated by capsular insufficiency due to underlying soft tissue disorders or multiple prior failed surgical procedures poses a challenging surgical problem.
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