AI Article Synopsis
- A system has been developed to identify chromosome number abnormalities during meiosis in the yeast Saccharomyces cerevisiae, focusing on spores with two specially marked chromosomes.
- Critically evaluates the technical steps involved and discusses potential biases in the procedure.
- The study includes data on the impact of 53 chemicals, finding that most induce diploid clones while a few lead to chromosome V non-disjunction.
Article Abstract
A system to detect chromosome number abnormalities occurring during meiosis in Saccharomyces cerevisiae is described. It is based on selection of spores carrying 2 multi-marked chromosomes V. Each step of the technical procedure is critically analyzed and the origin of some biases discussed. Selection and subsequent genetic analysis allow the estimation of the frequency of spontaneous and induced diploid and aneuploid n + 1 (diplo-V) spores. Data are reported concerning the effect of 53 chemical compounds. The great majority of active chemicals induce diploid clones while a minority cause non-disjunction of chromosome V.
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| http://dx.doi.org/10.1016/0027-5107(88)90025-5 | DOI Listing |
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