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Atypical Metastases from Prostate Cancer: Alpha-Methylacyl-Coenzyme A Racemase (AMACR) as a Potential Molecular Target in Prostate-Specific Membrane Antigen-Negative Prostate Adenocarcinoma.
Biomolecules
December 2024
Department of Translational Medicine, University of Ferrara, Via Aldo Moro 8, 44124 Ferrara, Italy.
Prostate cancer (PCa) is a high-prevalence disease usually characterized by metastatic spread to the pelvic lymph nodes and bones and the development of visceral metastases only in the late stages of disease. Positron Emission Tomography (PET) plays a key role in the detection of PCa metastases. Several PET radiotracers are used in PCa patients according to the stage and pathological features of the disease, in particular Ga/F-prostate-specific membrane antigen (PSMA) ligands.
View Article and Find Full Text PDFLeptomeningeal Dissemination in Choroid Plexus Tumors: Magnetic Resonance Imaging Appearance and Risk Factors.
Children (Basel)
January 2025
Department of Neuroradiology, University Hospital Würzburg, D-97080 Würzburg, Germany.
Background: Intracranial choroid plexus tumors (CPT) are rare and primarily affect young children. Leptomeningeal dissemination (LMD) has been reported not only in high-grade choroid plexus carcinoma (CPC) but also in lower histological grades; however, a systematic evaluation of CPT-specific imaging characteristics remains lacking.
Methods: We analyzed the imaging characteristics of LMD in a single-center pediatric cohort of 22 CPT patients (thirteen choroid plexus papilloma (CPP), six atypical choroid plexus papilloma (aCPP), three CPC), comparing LMD features with those of the primary tumor.
Physiological Responses to Aversive and Non-aversive Audiovisual, Audio, and Visual Stimuli.
Biol Psychol
January 2025
Department of Psychology, Institute for Mind and Brain, University of South Carolina, Columbia, SC 29201, USA. Electronic address:
We examined differences in physiological responses to aversive and non-aversive naturalistic audiovisual stimuli and their auditory and visual components within the same experiment. We recorded five physiological measures that have been shown to be sensitive to affect: electrocardiogram, electromyography (EMG) for zygomaticus major and corrugator supercilii muscles, electrodermal activity (EDA), and skin temperature. Valence and arousal ratings confirmed that aversive stimuli were more negative in valence and higher in arousal than non-aversive stimuli.
View Article and Find Full Text PDFA Very Atypical Meckel Diverticulum on 99mTcO4- Scintigraphy.
Clin Nucl Med
January 2025
From the Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA.
Typical Meckel diverticulum on 99mTcO4- scintigraphy usually appears early in the dynamic imaging in the right lower quadrant of the abdomen, without change of location during the study. We report a case of pathology-proven Meckel diverticulum a 7-year-old boy, which appeared only on the later part of the 99mTcO4- study in the midline upper pelvis which gradually changed location during the study.
View Article and Find Full Text PDFVulvar keratoacanthoma may be a malignant precursor: A case report and literature review.
Gynecol Oncol Rep
February 2025
People's Hospital of China Medical University, Department of Gynecology, People's Hospital of Liaoning Province, Shenyang, China.
Background: Keratoacanthoma is a relatively rare skin tumor, with vulvar keratoacanthoma being even more uncommon. Although the majority of keratoacanthomas exhibit a benign course, a subset of cases may show features of malignant potential, such as marginal invasion and recurrence.
Case: An 82-year-old female presented with a rapidly growing exophytic lesion on the left vulva, measuring 1.
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