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No Renal Toxicity After Repeated Treatment with Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in Patients with Unresectable Peritoneal Metastasis. | LitMetric

AI Article Synopsis

  • Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is an emerging treatment for patients with peritoneal metastasis (PM), aimed at examining renal toxicity after multiple procedures.
  • The study involved 43 patients who underwent at least 3 PIPAC cycles with cisplatin and doxorubicin, analyzing their post-operative renal health.
  • Results showed no significant acute or cumulative renal toxicity in these patients, confirming earlier findings and suggesting PIPAC is safe for renal function in this context.

Article Abstract

Background/aim: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a recent approach for intraperitoneal chemotherapy with promising results for patients with peritoneal metastasis (PM). The aim of this study was to report renal toxicity for patients who received at least 3 repeated PIPAC procedures.

Patients And Methods: All patients who underwent at least 3 PIPAC cycles of cisplatin (7.5 mg/m) and doxorubicin (1.5 mg/m) for unresectable PM from December 2015 to September 2017, were analysed regarding postoperative renal toxicity.

Results: Among 103 patients registered in a prospective single center database, 43 patients underwent at least 3 PIPAC cycles representing a total of 175 PIPAC. Median age was 59.8 years, 24 (55.8%) patients were female and median BMI was 22.2 kg/m Most common origins of PM were gastric 22 (51.1%) and ovarian 11 (25.6%) cancer. Median peritoneal cancer index (PCI) was 17 (range=5-39). For 39 (90.1%) patients, systemic chemotherapy was performed in addition to PIPAC. Forty-three (100%), 17 (39.5%), 14 (32.5%), 8 (18.6%), 3 (7%), 2 (4.7%) and 2 (4.7%) patients underwent three, four, five, six, seven, eight and nine PIPAC procedures, respectively. Repeated PIPAC did not induce significant acute nor cumulative renal toxicity in any patients.

Conclusion: Repeated PIPAC did not induce clinically relevant renal toxicity. This study confirms the previous published results in a larger group of patients.

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Source
http://dx.doi.org/10.21873/anticanres.13062DOI Listing

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