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Integrin-activating protein Invasin sustains long-term expansion of primary epithelial cells as 2D organoid sheets.
Proc Natl Acad Sci U S A
January 2025
Oncode Institute, Hubrecht Institute-Royal Netherlands Academy of Arts and Science, Utrecht 3584 CT, The Netherlands.
Matrigel/BME, a basement membrane-like preparation, supports long-term growth of epithelial 3D organoids from adult stem cells [T. Sato , , 262-265 (2009); T. Sato , , 1762-1772 (2011)].
View Article and Find Full Text PDFCharacterization of a novel acidic phospholipase A isolated from the venom of Bothrops mattogrossensis: From purification to structural modeling.
Int J Biol Macromol
December 2024
Laboratory of Cellular Immunology Applied to Health, Oswaldo Cruz Foundation, FIOCRUZ Rondônia, Porto Velho, RO, Brazil; Department of Medicine, Federal University of Rondonia (UNIR), Porto Velho, RO, Brazil. Electronic address:
Phospholipases A (PLAs) are highly prevalent in Bothrops snake venom and play a crucial role in inflammatory responses and immune cell activation during envenomation. Despite their significance, the specific role of PLAs from Bothrops mattogrossensis venom (BmV) in inflammation is not fully understood. This study sought to isolate and characterize a novel acidic PLA from BmV, designated BmPLA-A, and to evaluate its effects on human umbilical vein endothelial cells (HUVECs), with a specific focus on cytotoxicity, adhesion, and detachment.
View Article and Find Full Text PDFThe Effect of Purified Opharin Isolated from the Venom of King Cobra () in Modulating Macrophage Inflammatory Responses and Vascular Integrity.
Toxins (Basel)
December 2024
National Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, Kingsville, TX 78363, USA.
King cobra () venom comprises a diverse array of proteins and peptides. However, the roles and properties of these individual components are still not fully understood. Among these, Cysteine-rich secretory proteins (CRiSPs) are recognized but not fully characterized.
View Article and Find Full Text PDFThe nomenclatural status of "Anoplophallus maculatus" Cope, 1895, its consequences on the systematics of Lycodon subcinctus auctorum, and the description of a new species (Squamata: Colubridae).
Zootaxa
October 2024
Society for South East Asian Herpetology; Im Sand-3; D-69115 Heidelberg; Germany.
Article Synopsis
- The Malayan banded wolf snake (Lycodon subcinctus) has an intricate taxonomic history, with confusion surrounding its classification, particularly regarding the name Anoplophallus maculatus.
- Recent studies proposed raising a Chinese population of L. subcinctus to a species level, leading researchers to clarify that Anoplophallus maculatus actually refers to a different Neotropical snake.
- As a resolution, a new species name, Lycodon neomaculatus sp. nov., has been proposed for Chinese populations and is characterized by distinct color patterns and scalation, with its distribution being separate from L. subcinctus.
Current Technologies in Snake Venom Analysis and Applications.
Toxins (Basel)
October 2024
Centro Bioindustrial, Instituto Butantan, São Paulo 05503-900, SP, Brazil.
This comprehensive review explores the cutting-edge advancements in snake venom research, focusing on the integration of proteomics, genomics, transcriptomics, and bioinformatics. Highlighting the transformative impact of these technologies, the review delves into the genetic and ecological factors driving venom evolution, the complex molecular composition of venoms, and the regulatory mechanisms underlying toxin production. The application of synthetic biology and multi-omics approaches, collectively known as venomics, has revolutionized the field, providing deeper insights into venom function and its therapeutic potential.
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