AI Article Synopsis
- Depression is a significant risk factor for developing dementia, particularly dementia with Lewy bodies (DLB), and is linked to elevated levels of α-synuclein in the body.
- A study compared serum α-syn levels between 103 patients with major depressive disorder (MDD) and 132 healthy individuals, revealing that MDD patients had significantly higher α-syn levels regardless of age.
- These findings indicate that depression may not just be an early warning sign of DLB but also a potential contributor to its development.
Article Abstract
Objective: Epidemiologic studies have demonstrated that depression is a risk factor for dementia. In particular, dementia with Lewy bodies (DLB) has been noted to be highly relevant to depression. It has been suggested that α-synuclein (α-syn), a major component of Lewy bodies, is related to the onset and progression of DLB. To investigate the relationship between depression and DLB, we compared serum α-syn levels of patients with depression to those of healthy subjects.
Methods: The subjects were 103 inpatients with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), or DSM-5 major depressive disorder (MDD) and 132 healthy comparisons. Patients were recruited from Juntendo Koshigaya Hospital, Saitama, Japan, between June 2010 and November 2016. Serum α-syn levels were measured using an enzyme-linked immunosorbent assay kit. Serum α-syn levels were compared using a 2 (age group [<60 years versus ≥60 years]) × 2 (diagnosis [MDD versus comparison]) analysis of variance.
Results: There was no significant main effect of age (F = 1.167, df = 1, 231, p = 0.281). There was a significant main effect of diagnosis (F = 44.657, df = 1, 231, p <0.001), with higher α-syn levels in the MDD group versus the healthy comparison group, regardless of age.
Conclusion: The present results suggest that depression may affect the metabolism of α-syn; there is a possibility that depression is not only a prodromal symptom of DLB but also a causal risk factor for DLB.
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| http://dx.doi.org/10.1016/j.jagp.2018.10.015 | DOI Listing |
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