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Melarsomine hydrochloride (Cymelarsan) fails to cure horses with Trypanosoma equiperdum OVI parasites in their cerebrospinal fluid. | LitMetric

AI Article Synopsis

  • The study evaluated how effective melarsomine hydrochloride (Cymelarsan) is in treating horses with a nervous form of dourine, caused by the parasite Trypanosoma equiperdum.
  • Eight Welsh pony mares infected with the parasite were treated with daily doses of Cymelarsan for a week, while some control horses were left untreated or treated at different time intervals.
  • Although the treatment showed initial improvements, including parasite clearance from blood and stabilization of symptoms, live parasites reappeared in the cerebrospinal fluid of all treated horses, indicating that Cymelarsan is not effective for this condition.

Article Abstract

The aim of this study was to evaluate the ability of melarsomine hydrochloride (Cymelarsan) to cure horses suffering from a nervous form of dourine, a sexually-transmitted disease caused by Trypanosoma equiperdum. The recently described experimental model for assessing drug efficacy against horse trypanosomosis allowed us to obtain eight horses (Welsh pony mares) infected by T. equiperdum with parasites in their cerebrospinal fluid. The Cymelarsan treatment evaluated consisted of the daily administration of 0.5 mg/kg of Cymelarsan over 7 days. Two control horses remained untreated, three horses received the treatment 36 days p.i. and three horses received the treatment 16 days p.i. Following treatment, we observed parasite clearance in blood, stabilization of rectal temperature and a relative improvement in the mean packed cell volume levels for all treated horses. However, live parasites were later observed again in the CSF of all treated horses. Our results indicate the inability of Cymelarsan to reach Trypanozoon located in the central nervous system of infected horses and thus discourage the use of Cymelarsan to treat animals suffering from a nervous form of dourine.

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Source
http://dx.doi.org/10.1016/j.vetpar.2018.11.005DOI Listing

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