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Cerebrospinal fluid interleukin (IL)-10 and IL-10:IL-6 ratio as biomarkers for small B-cell lymphoproliferations with leptomeningeal dissemination. | LitMetric
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Cerebrospinal fluid interleukin (IL)-10 and IL-10:IL-6 ratio as biomarkers for small B-cell lymphoproliferations with leptomeningeal dissemination.

Myrto Costopoulos Rathana Kim Sylvain Choquet Karim Maloum Caroline Houillier Caroline Algrin Catherine Settegrana Juliette Villemonteix Martine Brissard Claire Quiney Sophie Bernard Frederic Davi Catherine Thieblemont Khe Hoang-Xuan Veronique Leblond Helene Merle-Beral Magali Le Garff-Tavernier

Semin Hematol

Department of Biological Hematology, Pitie-Salpetriere Hospital, Paris, France; Centre de Recherche des Cordeliers, Cell Death and Drug Resistance in Lymphoproliferative Disorders, Paris, France.

Published: October 2018

We here report for the first time that low levels of interleukin (IL)-10 do not exclude lymphomatous meningitis (LM) in B-cell lymphoproliferative disorders (CLPD). Unexpectedly, IL-10 levels and IL-10:IL-6 ratio in CLPD differed from the levels observed in diffuse large B-cell lymphoma (DLBCL). We report the usefulness of adding the IL-10:IL-6 ratio in order to potentially reveal more aggressive lymphomas: either a transformation or an association with another "hidden" lymphoma such as primary CNS lymphoma (PCNSL).

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http://dx.doi.org/10.1053/j.seminhematol.2017.06.005DOI Listing

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