In the present study, three new aconitine-type diterpenoid alkaloids brochyponines A-C (1-3) were isolated from the roots of Aconitum brevicalcaratum. Their structures were established on the basis of extensive spectroscopic analyses (IR, HR-ESI-MS, and 1D and 2D NMR). The NMR data of salt form for compound 1 in CDCl were also measured.
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http://dx.doi.org/10.1016/S1875-5364(18)30128-6 | DOI Listing |
Cardiovasc Ther
January 2025
Department of Cardiology XuanCheng City Central Hospital, Xuancheng, China.
Modern pharmacological studies have elucidated the presence of aconitine (AC) alkaloids, polysaccharides, and saponins as the primary bioactive constituents of Fuzi. Among these, benzoylaconine, a pivotal active compound, demonstrates notable pharmacological properties including antitumor, anti-inflammatory, and cardiovascular protective effects. In recent years, benzoylaconine has garnered significant attention in basic research on heart diseases, emerging as a focal point of investigation.
View Article and Find Full Text PDF<i>Ormocarpum trichocarpum</i> (Taub.) Engl. is a shrub or small tree harvested from the wild as a source of food, traditional medicines and wood.
View Article and Find Full Text PDFPhytochemistry
December 2024
Key Laboratory of Ethnic Medicine Resource Chemistry, Ministry of Education, Yunnan Minzu University, Kunming, 650500, Yunnan, People's Republic of China; Yunnan Key Laboratory of Chiral Functional Substance Research and Application, Yunnan Minzu University, Kunming, 650504, People's Republic of China. Electronic address:
Fibraurea recisa Pierre is a vine plant and its vine stems are used as a traditional Chinese medicine to treat heat toxin, constipation, diarrhea, sore throat, eye inflammation, carbuncles, and skin ulcers. The alkaloid chemical composition of this plant has been extensively studied; however, investigations into non-alkaloid components remain limited. In this study, phytochemical studies of the vine stems of F.
View Article and Find Full Text PDFJ Cardiothorac Surg
December 2024
Department of Emergency, The Affiliated Hospital of Yunnan University, Kunming, 650021, China.
Background: Aconitine has cardiotoxicity, but the mechanism of cardiotoxicity induced by aconitine is limited. The aim of this study was to investigate the mechanism of myocardial injury induced by aconitine.
Methods: Using aconitine, ROS inhibitor N-acetylcysteine(NAC), the autophagy activitor Rapamycin (Rap) or the P38/MAPK pathway activitor Dehydrocorydaline treats H9C2 cells.
Am J Transl Res
November 2024
Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional Ciudad de México, México.
The L. genus, belonging to the Moraceae family, includes around 850 species that are widely distributed in tropical and subtropical regions around the world; including the Eastern Mediterranean, Asia, Africa, Australia, and a large territory of America. Among the most important species are , , , , , Vahl, , , , and .
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