AI Article Synopsis
- - The study aimed to compare three methods for measuring central corneal clearance (CCC) during scleral lens wear: subjective evaluation via slit lamp, image processing using ImageJ, and measurements from an optic biometer (IOLMaster), with the optic biometer initially validated against OCT. - A total of 22 healthy eyes were first assessed, showing a strong correlation (r = 0.981) between IOLMaster and OCT measurements of CCC, with IOLMaster generally yielding higher values. In a second part, involving 61 eyes, the CCC measurements were found to be 238.66 μm (IOLMaster), 250.16 μm (SlitLamp), and 263.15 μm (ImageJ
Article Abstract
Purpose: To compare three methods to measure central corneal clearance (CCC) during scleral lens wear: subjective (slit lamp), image processed (ImageJ) and with an optic biometer. The optic biometer technique was validated in comparison to an OCT in the first part of the study.
Methods: Twenty-two eyes (11 subjects) with healthy corneas were recruited. Three measures of OCT with scleral lens and ten measurements of axial length (AL) with IOLMaster with and without lens were performed. For the second part, 61 eyes (35 subjects) enrolled in a clinical study were selected. Measurements of CCC were done with IOLMaster, SlitLamp and ImageJ.
Results: The measurements of CCC indirectly obtained with IOLMaster had a strong correlation with AS-OCT measurements (r = 0.981), showing a mean difference of 122.18 ± 46.05 μm (higher with IOLMaster). Regarding the second part, measurements of CCC were 238.66 ± 95.94 μm, 250.16 ± 124.31 μm and 263.15 ± 90.60 μm, for the IOLMaster, SlitLamp and ImageJ, respectively. The correlations were higher for ImageJ vs Subjective measure (r = 0.891) than for IOL vs Subjective (r = 0.748) and IOL vs ImageJ (r = 0.745). Analysis of differences and correlations between SlitLamp and ImageJ through time showed a mean difference of -32.28 ± 89.95 μm (r = 0.683) at V1month, 12.53 ± 59.46 μm (r = 0.850) at V6months and 11.57 ± 32.95 μm (r = 0.940) at V12months.
Conclusions: It is possible to measure CCC with IOLMaster, considering AL measured with and without lens and lens thickness. The three methods tested have good correspondence, showing that IOLMaster and ImageJ could be objective techniques to measure CCC. Also, it is possible to improve the agreement of subjective measures when compared to objective measures trough time.
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| http://dx.doi.org/10.1016/j.clae.2018.11.013 | DOI Listing |
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