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Change of CPAK class does not affect functional outcomes in robotic arm-assisted total knee arthroplasty performed with functional alignment.
Knee Surg Sports Traumatol Arthrosc
December 2024
Department of Orthopaedic Surgery, Azienda Ospedaliero-Universitaria Policlinico di Modena, University of Modena and Reggio-Emilia, Modena, Modena, Italy.
Article Synopsis
- The study aimed to evaluate how changes in post-operative coronal plane alignment of the knee (CPAK) affect functional outcomes after robotic arm-assisted total knee arthroplasty (RA-TKA) performed with functional alignment (FA).
- A total of 201 patients were included, with pre- and post-operative classifications of CPAK determined through CT imaging, and patient satisfaction assessed one year after surgery using the Forgotten Joint Score-12 and a satisfaction scale.
- Results showed that there was no significant difference in patient satisfaction between those who maintained their preoperative CPAK class and those who experienced changes, indicating that functional outcomes were stable regardless of CPAK class adjustments within a 'functional safe-zone'.
The Forgotten Tobamovirus Genes Encoding the 54 kDa Protein and the 4-6 kDa Proteins.
Viruses
October 2024
Graduate School of Plant Protection and Quarantine, Jeonbuk National University, Jeonju 54896, Republic of Korea.
This article reviews the literature concerning the largely forgotten tobamovirus gene products for which no functions have been ascribed. One of these gene products is the 54 kDa protein, representing the RNA-dependent RNA polymerase segment of the 183 kDa protein translated from the I-subgenomic mRNA, but which has been found only by in vitro translation and not . The other is a collection of small proteins, expressed from alternative reading frames (likely from internal ribosome entry sites) in either or both the gene or the gene.
View Article and Find Full Text PDFThe effects of sodium-glucose cotransporter 2 inhibitors on the 'forgotten' right ventricle.
ESC Heart Fail
October 2024
Department of Cardiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Article Synopsis
- Advances in diagnosis and treatment have highlighted how impaired right ventricular (RV) function significantly impacts heart failure prognosis, regardless of left ventricular ejection fraction.
- Right heart failure (RHF) can arise from multiple conditions, such as congenital heart disease and pulmonary arterial hypertension, and may occur after left ventricular assist devices are used.
- Recent studies focus on the use of SGLT2 inhibitors, particularly gliflozins, in improving RV function by addressing issues like RV overload and inflammation, while also discussing their implications for future clinical approaches and research.
Article Synopsis
- - Proton pump inhibitors (PPIs) are commonly used medications but can cause serious electrolyte imbalances, particularly low magnesium (hypomagnesaemia), which can lead to additional issues like low calcium (hypocalcaemia) and low potassium (hypokalaemia).
- - Long-term PPI use disrupts intestinal pH and interferes with magnesium transport mechanisms, which can lead to increased potassium loss and complications in calcium regulation.
- - These electrolyte imbalances can become severe and resistant to typical supplementation efforts, posing significant health risks for some patients who rely on chronic PPI therapy.
The forgotten p-versine and p-coversine family of functions revisited.
PLoS One
August 2024
Centre for Environmental Mathematics, Faculty of Environment, Science and Economy, University of Exeter, Penryn, United Kingdom.
This study delves into special class of generalized p-trigonometric functions, examining their connection to the established counterparts like p-cosine and p-sine functions. We here explore the new class of functions called the p-versine, p-coversine, p-haversine, and p-hacovercosine, by providing comprehensive definitions and properties. Grounded in the characteristics of p-cosine and p-sine functions, the newly proposed functions offer unique mathematical insights.
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