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- The study aimed to analyze the blood type and genetic makeup of a weak D blood group case in a Chinese Han individual.
- Researchers used serological tests to identify the blood phenotype and PCR-SBT for genotyping, revealing inconsistencies in results and specific gene variations.
- The findings suggested that the specific allele identified (c.1022T>A) should be classified as a weak partial D rather than a weak D in this population.
Article Abstract
Objective: To investigate the phenotype and genotype of the weak D blood group in one case of Chinese Han people.
Methods: Phenotype of blood sample was identified with serologic tests; PCR-SBT was applied for the analysis of genotype and RhD zygosity.
Results: Both saline and gel card tests demonstrated this case to be dCcee, which was contrary to glass bead card result. Some of the RBC D epitopes were negative.c.1022T>A allele was identified with PCR-SBT and the zygosity analysis showed this case to be D/d.
Conclusion: RHD*1022 A is more suitable to be categorized as weak partial D other than weak D in a Chinese Han people.
