The "why try" effect, a consequence of self-stigma, is a sense of behavioral futility that may worsen depression. This study examines the regressive model of self-stigma, the factor structure of a why try measure, and the pathway through which self-stigma leads to depression. Data from 291 people self-identifying with mental illness were collected through an online survey. Participants completed the Why Try Stigma Scale (WTSS) and measures of self-stigma and depression. Structural equation modeling was used to test the WTSS factor structure and path models. Reducing the WTSS from 12 to 6 items led to good fit. The regressive model of self-stigma was validated. A good fit was demonstrated for a model in which harm leads to unworthiness, then incapability, and then depression. The regressive model worsens sense of worthiness, which in turn affects personal capability, resulting in increased depression.
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http://dx.doi.org/10.1002/jcop.22144 | DOI Listing |
Psychopharmacol Bull
January 2025
Oslin, MD, Veterans Integrated Service Network 4, Mental Illness Research, Education and Clinical Center, Crescenz Veterans Affairs Medical Center and Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Background: Immunologic measures have been studied as predictors of who will respond to standard antidepressants. Two previous, small studies of pretreatment leukocyte mRNA expression levels of the cytokines macrophage migration inhibitory factor (MIF) and interleukin 1-beta (IL1-β) identified antidepressant treatment responders.
Methods: We tested these findings in 1,299 patients from the PRIME Care study, a multi-center pharmacogenetic depression treatment trial.
Front Public Health
January 2025
Department of Immunity, Quzhou Center for Disease Control and Prevention, Quzhou, Zhejiang, China.
Background: HFMD is a common infectious disease that is prevalent worldwide. In many provinces in China, there have been outbreaks and epidemics of whooping cough, posing a threat to public health.
Purpose: It is crucial to grasp the epidemiological characteristics of HFMD in Quzhou and establish a prediction model for HFMD to lay the foundation for early warning of HFMD.
Health Care Sci
December 2024
School of Computer Science and Engineering, Vellore Institute of Technology Vellore India.
Background: The global impact of the highly contagious COVID-19 virus has created unprecedented challenges, significantly impacting public health and economies worldwide. This research article conducts a time series analysis of COVID-19 data across various countries, including India, Brazil, Russia, and the United States, with a particular emphasis on total confirmed cases.
Methods: The proposed approach combines auto-regressive integrated moving average (ARIMA)'s ability to capture linear trends and seasonality with long short-term memory (LSTM) networks, which are designed to learn complex nonlinear dependencies in the data.
Chem Sci
December 2024
AI Lab, School of Engineering, Westlake University Hangzhou 310024 Zhejiang China
Generating molecules that bind to specific proteins is an important but challenging task in drug discovery. Most previous works typically generate atoms autoregressively, with element types and 3D coordinates of atoms generated one by one. However, in real-world molecular systems, interactions among atoms are global, spanning the entire molecule, leading to pair-coupled energy function among atoms.
View Article and Find Full Text PDFUnited European Gastroenterol J
December 2024
Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Background: Portal hypertension (PH) resulting from static and dynamic intrahepatic changes drives liver-related complications even after removing the underlying aetiological factor.
Objective: We investigated the impact of inflammation on the dynamic component of PH during disease regression in animal models of toxin-induced cirrhosis and patients with alcohol-related cirrhosis.
Methods: In mice, cirrhosis was induced via toxin application for 12 weeks followed by toxin-withdrawal allowing for one or 2 weeks of regression.
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