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Incidence and groups at risk for unexpected uterine leiomyosarcoma: a Dutch nationwide cohort study. | LitMetric

AI Article Synopsis

  • The study aimed to estimate the risk of uterine leiomyosarcoma (ULMS) in patients having gynecological surgery and identify at-risk groups for unrecognized ULMS.
  • Conducted in the Netherlands from 2000 to 2015, the study involved 262 cases of ULMS, revealing an overall incidence of 0.25% among patients.
  • Findings showed that women aged 40-50 with abnormal uterine bleeding are at greater risk for unexpected ULMS, while the risk is low in postmenopausal women and uncommon in those under 40.

Article Abstract

Objective: To estimate the risk of uterine leiomyosarcoma in patients undergoing gynecological surgery and also to identify groups at risk for unrecognized uterine leiomyosarcoma.

Methods: A national cohort study was performed evaluating all uterine leiomyosarcoma (ULMS) diagnosed in The Netherlands between January 2000 and September 2015. Cases were identified and supplied by the nationwide network and registry of histo- and cytopathology in The Netherlands (PALGA). Unexpected and expected ULMS were compared. Approval for this study was granted by the Medical Ethics Committee of all participating hospitals and by the review board of PALGA.

Results: 262 original cases were included. The overall incidence of ULMS in our study was 0.25% or 1:400 patients. The incidence of unexpected ULMS was 0.12% or 1:865 patients. Preoperatively, a malignancy was unexpected in 46% of the cases and expected in 54%. Abnormal uterine bleeding constituted most of the symptoms. 90% of women underwent abdominal hysterectomy and/or bilateral salpingo-oophorectomy.

Conclusions: Leiomyosarcoma are rare. Women aged 40-50 years with abnormal uterine bleeding are most at risk for unexpected ULMS. In contrast, this risk is low in postmenopausal women. ULMS were highly uncommon in women aged under 40 years.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328517PMC
http://dx.doi.org/10.1007/s00404-018-4949-4DOI Listing

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