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| http://dx.doi.org/10.21037/atm.2018.08.15 | DOI Listing |
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Phase Ib study of PRT543, an oral protein arginine methyltransferase 5 (PRMT5) inhibitor, in patients with advanced splicing factor-mutant myeloid malignancies.
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January 2025
Department of Medicine; Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Article Synopsis
- This study focuses on PRT543, a new oral medication designed to inhibit PRMT5, an enzyme implicated in the growth of certain blood cancers.
- It specifically investigates the effects of PRT543 in patients suffering from advanced myeloid malignancies that have mutations in splicing factors, which are crucial for proper gene expression and can contribute to cancer progression.
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Point-of-care additive manufacturing: state of the art and adoption in Spanish hospitals during pre to post COVID-19 era.
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Diagnostic Imaging Department, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, 08025, Barcelona, Spain.
Background: 3D technologies [Virtual and Augmented 3D planning, 3D printing (3DP), Additive Manufacturing (AM)] are rapidly being adopted in the healthcare sector, demonstrating their relevance in personalized medicine and the rapid development of medical devices. The study's purpose was to understand the state and evolution of 3DP/AM technologies at the Point-of-Care (PoC), its adoption, organization and process in Spanish hospitals and to understand and compare the evolution of the models, clinical applications, and challenges in utilizing the technology during the COVID-19 pandemic and beyond.
Methods: This was a questionnaire-based qualitative and longitudinal study.
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Cardiovascular Diseases Research Institute, Tehran Heart Center, Tehran University of Medical Sciences, TUMS, Tehran, 1995614331, Iran.
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View Article and Find Full Text PDFImpact of adding warm asphalt mix additives on recycling milled coatings: performance evaluation.
Environ Sci Pollut Res Int
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Department of Civil Engineering, University of São Paulo, Av. Prof. Almeida Prado 83, São Paulo, SP, 05508-070, Brazil.
The use of warm mix asphalt (WMA) and reclaimed asphalt pavement (RAP) technologies presents challenges in optimizing binder activation and mechanical performance in asphalt mixtures. This study aimed to evaluate the effects of three WMA additives (sunflower oil, WarmGrip®, and natural zeolite) and different RAP contents (30% and 70%) on the rheological and mechanical properties of recycled asphalt mixtures. The research focused on assessing the degree of RAP binder activation, determining the extent of partial activation, and analyzing the impact on tensile strength, moisture resistance, modulus, fatigue life, and deformation resistance.
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