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Extracellular matrix-based intracortical microelectrodes: Toward a microfabricated neural interface based on natural materials. | LitMetric

AI Article Synopsis

  • Researchers developed implantable neural electrodes (NEs) using a microfabrication technique with natural materials to create an extracellular matrix (ECM)-based design.
  • This design minimizes non-natural substances in the brain and allows the electrodes to become softer after implantation, matching the brain tissue's elasticity and reducing inflammation.
  • Preliminary tests show that ECM-NEs cause less inflammation compared to traditional inorganic electrodes, and they have been used for recording brain activity in the rat motor cortex.

Article Abstract

Extracellular matrix (ECM)-based implantable neural electrodes (NEs) were achieved using a microfabrication strategy on natural-substrate-based organic materials. The ECM-based design minimized the introduction of non-natural products into the brain. Further, it rendered the implants sufficiently rigid for penetration into the target brain region and allowed them subsequently to soften to match the elastic modulus of brain tissue upon exposure to physiological conditions, thereby reducing inflammatory strain fields in the tissue. Preliminary studies suggested that ECM-NEs produce a reduced inflammatory response compared with inorganic rigid and flexible approaches. intracortical recordings from the rat motor cortex illustrate one mode of use for these ECM-NEs.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258041PMC
http://dx.doi.org/10.1038/micronano.2015.10DOI Listing

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