Suppresses the Humoral Immune System to Overcome Defense Mechanism of .

has become a notorious pest of cruciferous crops all over the world. Delta-endotoxins of are widely used insecticidal proteins for controlling . However, the interaction mechanism of with the immune system of , at the genomic level, is still unclear. This study explored the immune response of to , at different time intervals, 6 h, 12 h, 18 h, 24 h, and 36 h, by using RNA-Sequencing (RNA-Seq) and RT-qPCR. In total, 167 immunity-related genes were identified and placed into different families, including pattern recognition receptors (PRRs), signal modulators, immune pathways (Toll, IMD, and JAK/STAT), and immune effectors. It is worth mentioning that the analyses of the differentially expressed immunity-related genes revealed that most of the differentially expressed genes (DEGs) (87, 56, 76, 67, and 73 genes) were downregulated in following oral infection at 6 h, 12 h, 18 h, 24 h, and 36 h. Interestingly, our RNA-Seq analysis also revealed reduced expression of antimicrobial peptides, that play a vital role in the humoral immune system of . This study demonstrates that plays a novel role in controlling , by suppressing the immune system.