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American Glaucoma Society-American Academy of Ophthalmology Position Statement on Nicotinamide Use for Glaucoma Neuroprotection.
Ophthalmol Glaucoma
January 2025
Department of Ophthalmology, Columbia University Irving Medical Center, New York, New York, USA; Bernard and Shirlee Glaucoma Research Laboratory, Columbia University Irving Medical Center, New York, New York, USA.
Macrophage membrane-camouflaged pure-drug nanomedicine for synergistic chemo- and interstitial photodynamic therapy against glioblastoma.
Acta Biomater
January 2025
Shanghai Frontiers Science Center of Drug Target Identification and Delivery, National Key Laboratory of Innovative Immunotherapy, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:
Glioblastoma (GBM) persists as a highly fatal malignancy, with current clinical treatments showing minimal progress over years. Interstitial photodynamic therapy (iPDT) holds promise due to its minimally invasive nature and low toxicity but is impeded by poor photosensitizer penetration and inadequate GBM targeting. Here, we developed a biomimetic pure-drug nanomedicine (MM@CT), which co-assembles the photosensitizer chlorin e6 (Ce6) and the first-line chemotherapeutic drug (temozolomide, TMZ) for GBM, then camouflaged with macrophage membranes.
View Article and Find Full Text PDFCondylar Changes in Adult Patients with Unilateral Posterior Crossbite Following Microimplant-Assisted Rapid Palatal Expansion: A Retrospective CBCT Study.
J Stomatol Oral Maxillofac Surg
January 2025
Department of Orthodontics, Hubei-MOST KLOS & KLOBM, School & Hospital of Stomatology, Wuhan University, Wuhan, China.. Electronic address:
Objectives: This study aims to assess the alterations in condylar positioning in adult skeletal Class I patients with unilateral posterior crossbite after microimplant-assisted rapid palatal expansion (MARPE) treatment.
Methods: This retrospective study involving 30 participants (10 males, 20 females) average age 22.9 ± 4.
Brachial arterial adaptations in college baseball players: Differences between pitchers and fielders.
J Sci Med Sport
December 2024
Faculty of Sport Sciences, Waseda University, Japan.
Objectives: Although exercise-induced vascular adaptations have been extensively reported in racket sports athletes, the applicability of these findings to athletes in other overhead sports is unclear. This study aimed to investigate exercise-induced vascular adaptations in college male baseball players. Furthermore, since the training frequency of the upper arm may differ by baseball playing position, this study also focused on playing position-specific differences in brachial arterial adaptations.
View Article and Find Full Text PDFSynergistic Effects of NO/HS Gases on Antibacterial, Anti-inflammatory, and Analgesic Properties in Oral Ulcers Using a Gas-Releasing Nanoplatform.
Acta Biomater
January 2025
School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, P. R. China. Electronic address:
Article Synopsis
- Oral mucosal wounds are susceptible to inflammation and complications due to exposure to microorganisms, which can hinder daily activities and diminish quality of life.
- A novel therapeutic nanoplatform, DATS@Arg-EA-SA, has been developed to target these wounds by combining guanidinated dendritic peptides with diallyl trisulfide (DATS), providing both antimicrobial and anti-inflammatory effects.
- This nanoplatform effectively eliminates various bacteria, including drug-resistant strains like MRSA, and enhances healing by promoting the transition of inflammatory cells and alleviating pain, making it a promising solution for oral wound treatment.
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