AI Article Synopsis
- The study evaluated how different physico-chemical properties of lipids affect the solubility of imatinib mesylate (IM) and developed a predictive statistical model based on these properties.
- A quantitative structure-solubility relationship (QSSR) approach was utilized to connect lipid characteristics with IM solubility levels, using multiple linear regression to generate predictive equations.
- Results showed that glyceryl monostearate had the highest IM solubility (6.19%) while behenic acid had the lowest (0.01%), indicating that factors like alkyl chain length and hydrogen bonding significantly influence IM's solubility in lipids, with the predictive model showing good accuracy (R = 0.912).
Article Abstract
The physico-chemical properties of lipids influencing the solubilisation of imatinib mesylate (IM) in lipid matrix were evaluated and a statistical model to predict the same has been derived in the present study. After experimental quantification of IM solubility in various lipids, Hansen Hildebrand's total solubility parameters were calculated in order to study the role of various forces connected to lipid-drug interaction. To develop a relationship between the various descriptors of the lipids and experimental solubility of IM in lipids (% w/w), quantitative structure-solubility relationship (QSSR) was used. To generate equations that can predict the solubility of IM in lipids (%w/w), multiple linear regression was used. Amongst the various lipids tested, glyceryl monostearate and behenic acid solubilised the highest (6.19 ± 0.22%) and lowest (0.01 ± 0.01%) amounts of IM respectively. Our results suggested that alkyl chain length, polarity of the lipids, index of cohesive interaction in solids, estimated number of hydrogen bonds that would be accepted by the solute from water molecules in an aqueous solution, estimated number of hydrogen bonds that would be donated by the solute to water molecules in an aqueous solution and solvent accessible surface area collectively play a significant role in solubilising IM in the lipids. The equation developed could predict the solubility of IM in lipids with good accuracy (R = 0.912).
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| http://dx.doi.org/10.1016/j.colsurfb.2018.11.033 | DOI Listing |
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