Long-term exposures to Hypersaline particles associated with increased levels of Homocysteine and white blood cells: A case study among the village inhabitants around the semi-dried Lake Urmia.

The dried bed of the world's second largest permanent Hypersaline lake, Lake Urmia, acts as a Hypersaline particle emission source. In the present study we aim to assess the health impact of this disaster and examine the association of Hypersaline particles with total and differential white blood cell counts (WBC) and homocysteine (Hcy), the biomarkers of cardiovascular diseases, in the residents around Lake Urmia. Based on the previous study three regions were selected as clean and polluted regions for ambient particulate matter (APM) from 2008 to 2015. Concentration of APM (PM, PM and PM; particulate matter with aerodynamic diameter of less than 10, 2.5 and 1 µm, respectively) was measured in the selected regions and totally, 123 participants were selected randomly from villagers who have lived in the selected regions for at least eight years. Biomarkers and covariates were measured in the selected regions and were analyzed using multiple linear regression models. We found a statistically significant association between APM and selected biomarkers (Hcy, total WBC, neutrophil, monocyte, lymphocyte and basophile) in the polluted regions. These results are consistent with our hypothesis that long-term exposure to Hypersaline particles originated from drying Urmia Hypersaline Lake is related to increased cardiovascular risk biomarkers.