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Human Exposure to Asbestos in Central Asian Countries and Health Effects: A Narrative Review.
Med Lav
December 2024
Department of Health Sciences; Course of Research Doctorate in Public Health Sciences, University of Milan, Milan, Italy/Occupational Health Unit, Santi Paolo e Carlo Hospital, Milan, Italy.
The discovery of the detrimental effects of asbestos on human health came long after its widespread use, with the first scientific evidence of asbestos-related diseases emerging in the late 19th and early 20th centuries. Despite efforts to ban its use, asbestos continues to be mined and used in Central Asia (as well as in Russia, China, and other countries). To gain a deeper understanding of the situation in Central Asia, we have conducted a systematic review of scientific literature on the use of asbestos, exposure assessment, and health consequences of asbestos exposure in this geographic area.
View Article and Find Full Text PDF[Mortality due to mesothelioma and asbestosis in Campania Region (Southern Italy): perspectives for reducing asbestos exposure].
Epidemiol Prev
December 2024
Dipartimento di Medicina, Epidemiologia, Igiene del lavoro e ambientale, Istituto Nazionale per l'Assicurazione contro gli Infortuni sul Lavoro, Roma.
Objectives: to provide an overview of the geographical distribution of mesothelioma and asbestosis deaths in the Campania Region (Southern Italy) occurred from 2005 to 2018 and to identify areas at higher risk.
Design: for each municipality, Standardized Mortality Ratios (SMRs) for mesothelioma and asbestosis have been estimated from the mortality data provided by the Italian National Institute of Statistics (Istat). Deaths for which mesothelioma and asbestosis were identified as the underlying causes, according to the classification system ICD-10 codes (C45 and J61, respectively), were included.
Copper chelation redirects neutrophil function to enhance anti-GD2 antibody therapy in neuroblastoma.
Nat Commun
December 2024
School of Biomedical Sciences, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW, Australia.
Anti-disialoganglioside (GD2) antibody therapy has provided clinical benefit to patients with neuroblastoma however efficacy is likely impaired by the immunosuppressive tumor microenvironment. We have previously defined a link between intratumoral copper levels and immune evasion. Here, we report that adjuvant copper chelation potentiates anti-GD2 antibody therapy to confer durable tumor control in immunocompetent models of neuroblastoma.
View Article and Find Full Text PDF[Update. Inventory of occupational exposure to asbestos with particular reference to Tuscan worker].
Epidemiol Prev
November 2024
SC Epidemiologia dei Fattori di Rischio e degli Stili di Vita, Istituto per lo Studio, la Prevenzione e la Rete Oncologica (ISPRO), Firenze.
This Catalogue is a collection of information on the use of raw asbestos and asbestos-containing materials used in several industries and occupational activities, with particular attention to the situation of Tuscany, a region of Central Italy. The work was developed at the Institute for Cancer Research, Prevention and Clinical Network (ISPRO) of Florence, where epidemiologic research and surveillance activities have been developing since 1988 and where the coordination and evaluation of the regional health surveillance programme provided to past asbestos workers started in 2016 and is still ongoing. The Catalogue aims at being a working tool for all health professionals engaged in examining and classifying the occupational asbestos exposures of subjects both affected by diseases that could be associated to this carcinogen and examined within the regional health surveillance programme.
View Article and Find Full Text PDFFerritin adsorption onto chrysotile asbestos fibers influences the protein secondary structure.
Heliyon
October 2024
Department of Life Science, University of Trieste, via via Valerio 28-28/1, 34127, Trieste, Italy.
Asbestos fiber exposure triggers chronic inflammation and cancer. Asbestos fibers can adsorb different types of proteins. The mechanism of this adsorption, not yet completely understood, has been studied in detail mainly with serum albumin and was shown to induce structural changes in the bound protein.
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