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Comparing Prescription Drug Saving Platforms for Dermatology: A Cost Analysis of Mark Cuban Cost Plus Drugs, GoodRx, and Amazon RxPass.
J Am Acad Dermatol
January 2025
Harvard Medical School, Boston, MA; Department of Dermatology, Brigham and Women's Hospital, Boston, MA.
Was extinction of New Zealand's avian megafauna an unavoidable consequence of human arrival?
Sci Total Environ
January 2025
School of Biological Sciences, University of Adelaide, Adelaide, SA 5000, Australia; The Environment Institute, University of Adelaide, Adelaide, SA 5000, Australia; Center for Macroecology, Evolution, and Climate, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark; Center for Global Mountain Biodiversity, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark. Electronic address:
Human overexploitation contributed strongly to the loss of hundreds of bird species across Oceania, including nine giant, flightless birds called moa. The inevitability of anthropogenic moa extinctions in New Zealand has been fiercely debated. However, we can now rigorously evaluate their extinction drivers using spatially explicit demographic models capturing species-specific interactions between moa, natural climates and landscapes, and human colonists.
View Article and Find Full Text PDFProduction of Amyloid-β in the Aβ-Protein-Precursor Proteolytic Pathway Is Discontinued or Severely Suppressed in Alzheimer's Disease-Affected Neurons: Contesting the 'Obvious'.
Genes (Basel)
January 2025
Division of Molecular Medicine, Children's Hospital, Boston, MA 02115, USA.
A notion of the continuous production of amyloid-β (Aβ) via the proteolysis of Aβ-protein-precursor (AβPP) in Alzheimer's disease (AD)-affected neurons constitutes both a cornerstone and an article of faith in the Alzheimer's research field. The present Perspective challenges this assumption. It analyses the relevant empirical data and reaches an unexpected conclusion, namely that in AD-afflicted neurons, the production of AβPP-derived Aβ is either discontinued or severely suppressed, a concept that, if proven, would fundamentally change our understanding of the disease.
View Article and Find Full Text PDFAntiseizure medications for Lennox-Gastaut Syndrome: Comprehensive review and proposed consensus treatment algorithm.
Epilepsy Behav
January 2025
Department of Neurosurgery, Mass General Brigham, Harvard Medical School, Boston, MA 02115, USA.
Lennox-Gastaut syndrome (LGS) is a severe, childhood-onset developmental and epileptic encephalopathy characterized by multiple drug-resistant seizure types, specific electroencephalogram (EEG) patterns, and significant cognitive and behavioral impairments. To date, eight anti-seizure medications (ASMs) have been specifically approved by the U.S.
View Article and Find Full Text PDFExamining the influence of encoding and retrieval contexts on 2- to 4-year-olds' acquisition of nouns and verbs.
Br J Dev Psychol
January 2025
Department of Psychology, Trinity University, San Antonio, Texas, USA.
This study investigates whether the context in which a word is learnt affects noun and verb learning. There is mixed evidence in studies of noun learning, and no studies of background perceptual context in verb learning. Two-, three-, and four-year-olds (n = 162) saw a novel object moved in a novel way while hearing four novel words, either nouns or verbs.
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