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Highlights of Cardiovascular Disease Prevention Studies Presented at the 2024 European Society of Cardiology Congress.
Curr Atheroscler Rep
December 2024
Department of Medicine, The Aga Khan University, Karachi, 74800, Pakistan.
Purpose Of Review: To summarize selected late-breaking science on cardiovascular disease (CVD) prevention presented at the 2024 European Society of Cardiology (ESC) Congress.
Recent Findings: Key studies from the 2024 ESC Congress highlight advances in (CVD) management. Apolipoprotein A-1 infusions reduced risk in acute myocardial infarction patients with high LDL cholesterol.
MEDI1814 selectively reduces free Aβ42 in cerebrospinal fluid of non-clinical species and Alzheimer's disease patients.
Alzheimers Dement
November 2024
BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Introduction: Small molecules and antibodies are being developed to lower amyloid beta (Aβ) peptides.
Methods: We describe MEDI1814, a fully human high-affinity monoclonal antibody selective for Aβ, the pathogenic self-aggregating species of Aβ.
Results: MEDI1814 reduces free Aβ without impacting Aβ in the cerebrospinal fluid of rats and cynomolgus monkeys after systemic administration.
White matter lipid alterations during aging in the rhesus monkey brain.
Geroscience
September 2024
Department of Anatomy & Neurobiology, Boston University Chobanian & Avedisian School of Medicine, 72 East Concord St, Room L1004, Boston, MA, 02118, USA.
The brain of higher organisms, such as nonhuman primates, is particularly rich in lipids, with a gray to white matter ratio of approximately 40 to 60%. White matter primarily consists of lipids, and during normal aging, it undergoes significant degeneration due to myelin pathology, which includes structural abnormalities, like sheath splitting, and local inflammation. Cognitive decline in normal aging, without neurodegenerative diseases, is strongly linked to myelin pathology.
View Article and Find Full Text PDFDrug burden index of people ageing with intellectual disability and cognitive complaints attending a specialist memory service.
J Intellect Disabil Res
December 2024
National Intellectual Disability Memory Service, Tallaght University Hospital, Dublin, Ireland.
Article Synopsis
- Medications that can cause sedation or have anticholinergic effects pose risks for those with cognitive issues, especially in individuals with intellectual disabilities (ID), who may experience increased frailty and adverse effects.
- A study assessed the drug burden in a group of patients with ID who were referred for cognitive evaluation, finding that a majority were on multiple medications, with significant use of sedatives and anticholinergics.
- Results indicated that individuals with psychiatric comorbidities and certain types of ID had higher drug burden index scores, suggesting a need for careful medication management in this population.
Tandem Autologous Stem Cell Transplantation Does Not Benefit High-Risk Myeloma Patients in the Maintenance Era: Real-World Results from The Canadian Myeloma Research Group Database.
Transplant Cell Ther
September 2024
Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.
In patients with multiple myeloma (MM), the presence of high-risk cytogenetic abnormalities is associated with worse disease control and survival. Autologous stem cell transplant (ASCT) does benefit these patients. Tandem transplantation has been explored as a means to deepen responses and further improve survival however, its role remains controversial.
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