Objective: In this study we present a novel approach for inducing vasoconstriction by pulsed electrical treatment delivered via endovascular electrodes, which can be used in cases where external access to the vessel is limited.
Methods: Using computer simulations, we optimized various geometries of endovascular electrodes to maximize the induced electric field on the arterial wall. Using the optimal configuration parameters, we investigated endovascular induced vasoconstriction in both the carotid and femoral sheep arteries.
Results: Endovascular electrodes induced robust vasoconstriction in the carotid artery of sheep, showing gradual recovery following treatment. Moreover, the obtained vasoconstriction was accompanied by a sevenfold decrease in blood loss for 100% constriction, compared with no treatment (6ml vs 42ml, p<0.001). The femoral artery was less amenable to the electrical treatment, which we hypothesize results from the reduced density of the sympathetic system's innervation of the adventitia of the sheep femoral artery, as was validated by immunohistochemical analysis. Finally, treatment safety was validated through arterial histological studies, in which no adverse effect was observed, and through computer modeling, which depicted a negligible temperature increase.
Significance: These results are an important step toward developing a novel approach for inducing reversible and controlled vasoconstriction in arteries that are remote from access.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1109/TBME.2018.2883212 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Laser Welding of Micro-Wire Stent Electrode as a Minimally Invasive Endovascular Neural Interface.
Micromachines (Basel)
December 2024
Laboratory for Neural Interface and Brain Computer Interface, Engineering Research Center of AI & Robotics, Ministry of Education, Shanghai Engineering Research Center of AI & Robotics, MOE Frontiers Center for Brain Science, State Key Laboratory of Medical Neurobiology, Institute of AI & Robotics, Academy for Engineering & Technology, Fudan University, Shanghai 200433, China.
Minimally invasive endovascular stent electrodes are an emerging technology in neural engineering, designed to minimize the damage to neural tissue. However, conventional stent electrodes often rely on resistive welding and are relatively bulky, restricting their use primarily to large animals or thick blood vessels. In this study, the feasibility is explored of fabricating a laser welding stent electrode as small as 300 μm.
View Article and Find Full Text PDFA 10-year journey towards clinical translation of an implantable endovascular BCI a keynote lecture given at the BCI society meeting in Brussels.
J Neural Eng
January 2025
Synchron, Inc., Brooklyn, New York, USA and Vascular Bionics Laboratory, Department of Medicine, The University of Melbourne, Melbourne, Australia.
In the rapidly evolving field of brain-computer interfaces (BCIs), a novel modality for recording electrical brain signals has quietly emerged over the past decade. The technology is endovascular electrocorticography (ECoG), an innovation that stands alongside well-established methods such as electroencephalography, traditional ECoG, and single/multi-unit activity recording. This system was inspired by advancements in interventional cardiology, particularly the integration of electronics into various medical interventions.
View Article and Find Full Text PDFEndocisternal interfaces for minimally invasive neural stimulation and recording of the brain and spinal cord.
Nat Biomed Eng
November 2024
Department of Neurosurgery, University of Texas Medical Branch, Galveston, TX, USA.
Minimally invasive neural interfaces can be used to diagnose, manage and treat many disorders, with reduced risks of surgical complications. However, endovascular probes lack access to key cortical, subcortical and spinal targets, and are not typically explantable after endothelialization. Here we report the development and testing, in sheep, of endocisternal neural interfaces that approach brain and spinal cord targets through inner and outer spaces filled with cerebrospinal fluid.
View Article and Find Full Text PDFIntravascular delivery of an ultraflexible neural electrode array for recordings of cortical spiking activity.
Nat Commun
November 2024
Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Article Synopsis
- - Intracranial neural electrodes offer valuable insights for research and treatment of neurological diseases but require invasive surgery, which can harm brain tissue and disrupt functions.
- - New endovascular neural devices present a less invasive alternative but currently lack the capability to capture single-unit activity in larger animals and humans, limiting their clinical use.
- - The ultraflexible implantable neural electrode (uFINE-I) demonstrates successful implantation in sheep, recording high-resolution neural activity with minimal tissue damage, paving the way for future applications in brain-machine interfaces and neurological treatments.
A leadless power transfer and wireless telemetry solutions for an endovascular electrocorticography.
J Neural Eng
November 2024
School of Biomedical Engineering, The University of Sydney, Camperdown, NSW 2050, Australia.
. Endovascular brain-computer interfaces (eBCIs) offer a minimally invasive way to connect the brain to external devices, merging neuroscience, engineering, and medical technology. Currently, solutions for endovascular electrocorticography (ECoG) include a stent in the brain with sensing electrodes, a chest implant to accommodate electronic components to provide power and data telemetry, and a long (tens of centimeters) cable travel through vessels with a set of wires in between.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!