In-Cell NMR Spectroscopy of Intrinsically Disordered Proteins.

Proteomics

Department of Chemistry, University at Albany, State University of New York, Albany, NY, 12222, USA.

Published: March 2019

This review summarizes the results of in-cell Nuclear Magnetic Resonance, NMR, spectroscopic investigations of the eukaryotic and prokaryotic intrinsically disordered proteins, IDPs: α-synuclein, prokaryotic ubiquitin-like protein, Pup, tubulin-related neuronal protein, Tau, phenylalanyl-glycyl-repeat-rich nucleoporins, FG Nups, and the negative regulator of flagellin synthesis, FlgM. The results show that the cellular behavior of IDPs may differ significantly from that observed in the test tube.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004275PMC
http://dx.doi.org/10.1002/pmic.201800055DOI Listing

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