Pylephlebitis as a Complication of Cholangitis and Sepsis in an HIV-Positive Patient.

Dig Dis Sci

Division of Cardiology, Faculty of Medicine and Psychology, University of Rome "Sapienza, " Sant'Andrea Hospital, Rome, Italy.

Published: June 2019

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http://dx.doi.org/10.1007/s10620-018-5391-yDOI Listing

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Article Synopsis
  • - Pylephlebitis is a serious condition characterized by the infection and inflammation of the portal vein, often arising from abdominal infections.
  • - The case discussed involves a patient with hypermucoviscous pneumonia who developed pylephlebitis, treated with antibiotics and anticoagulants, but ultimately suffered liver failure.
  • - Persistent bacteremia after pneumonia can lead to complications like portal vein inflammation, highlighting the need for thorough monitoring and investigation in such cases.
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Right-sided infective endocarditis is less common than left-sided endocarditis and can be a difficult clinical diagnosis. The presence of intracardiac devices is a major risk factor. The presentation is less clear than left-sided forms because of the presence of respiratory symptoms and the absence of systemic embolization.

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Pylephlebitis, which is a type of septic thrombophlebitis of the portal vein, is a rare and life-threatening complication that commonly occurs following appendicitis. However, nonspecific abdominal complaints and fever can impede the diagnosis of pylephlebitis. Timely use of appropriate antibiotics and anticoagulants is paramount for treating this condition.

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Portal vein thrombophlebitis is a rare complication that can occur in various hypercoagulable states, including COVID-19. We are presenting a 74-year-old female with a history of hypertension, diabetes, and lymphoma who contracted the COVID-19 infection and presented with persistent fever, leukocytosis, and mild epigastric tenderness. She developed hypotension, acute hypoxic respiratory failure, and worsening leukocytosis with bandemia and was diagnosed with portal vein thrombosis (PVT) and superior mesenteric vein thrombosis.

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Background: Pylephlebitis is an extremely rare form of septic thrombophlebitis involving the portal vein, carrying high rates of morbidity and mortality.

Case Summary: We present a case of a 42-year-old male with no past medical history who presented with acute onset of abdominal pain and altered mental status with laboratory tests demonstrating new-onset acute liver failure. Pylephlebitis was determined to be the underlying etiology due to subsequent workup revealing polymicrobial gram-negative anaerobic bacteremia and complete thrombosis of the main and left portal veins.

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