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| http://dx.doi.org/10.1128/MCB.00482-18 | DOI Listing |
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Grp78 is required for intestinal Kras-dependent glycolysis proliferation and adenomagenesis.
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In development of colorectal cancer, mutations in are often followed by mutations in oncogene The latter changes cellular metabolism and is associated with the Warburg phenomenon. Glucose-regulated protein 78 () is an important regulator of the protein-folding machinery, involved in processing and localization of transmembrane proteins. We hypothesize that targeting in and ()-mutant intestines interferes with the metabolic phenotype imposed by mutations.
View Article and Find Full Text PDFAquaphotomics for monitoring of groundwater using short-wavelength near-infrared spectroscopy.
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Aquaphotomics Research Department, Graduate School of Agricultural Science, Kobe University, 1-1, Rokkodai, Nada, Kobe 657-8501, Japan. Electronic address:
Water spectrum of any aqueous system contains information about OH covalent and hydrogen bonds that are highly influenced by the environment and the rest of the molecules in the system. When aquaphotomics is used to analyze the water near infrared (NIR) spectra, the information about the water molecular structure can be obtained as a function of internal and external factors. The objective of this research is to apply aquaphotomics analysis to evaluate different groundwaters by using their NIR unique spectral pattern, robust to external influences of temperature and humidity, that can potentially be used for water type identification and screening practice.
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In near-infrared spectroscopy (NIRS), the linear relationship between absorbance and an absorbing compound concentration has been strictly defined by the Bouguer-Beer-Lambert law only for the case of transmission measurements of nonscattering media. However, various quantitative calibrations have been successfully built both on reflectance measurements and for scattering media. Although the lack of linearity for scattering media has been observed experimentally, the sound multivariate statistics and signal processing involved in chemometrics have allowed us to overcome this problem in most cases.
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