Due to its unique physical and chemical properties, gold has been widely applied as electrode material for various applications. In recent years, with the increasing requirement on the electrode performance, researchers attempted to involve nanostructures into the electrode through various routes, which demonstrated the performance improvement but still are limited by the process complexity, toxic agents and high cost. In this work, a simple and fast electrochemical surface modification process of gold electrodes was developed. Compared with commonly used nanostructured gold electrode synthesis or modification processes, this electrochemical modification process is based on electrochemical migration phenomenon and can be completed in short time (<90 seconds) without using caustic chemicals. It is hypothesized that this high efficiency formation mechanism is based on electrochemical dissolution of cations from and redeposition to the electrode surface. The evolution of nanostructures from nanopores under low current density processing conditions to nanodendrites under high current density conditions was observed.
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http://dx.doi.org/10.1166/jnn.2019.16013 | DOI Listing |
Background: The advent of disease-modifying therapies in Alzheimer's disease (AD) necessitates a nuanced understanding of how therapies impact disease processes. Over the past decades, AD clinical trials have primarily relied on classical statistical analysis methodology such as the mixed model for repeated measures (MMRM) to estimate treatment effects. These conventional treatment effect quantifications are given as group differences in clinical outcome measures at a single visit.
View Article and Find Full Text PDFBackground: TAR-DNA-binding protein 43 (TDP43), is a pathologic marker in neurodegenerative diseases including frontotemporal lobar degeneration and amyotrophic lateral sclerosis. The aggregation of TDP-43, a crucial RNA-binding protein, is a consequence of post-translational modifications (PTMs) that disrupt its normal function. PTMs such as phosphorylation and ubiquitination contribute to the aberrant accumulation of TDP-43 aggregates, leading to neurodegenerative disorders like amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Washington University in St. Louis, School of Medicine, St. Louis, MO, USA; Washington University School of Medicine, St. Louis, MO, USA; Knight Alzheimer Disease Research Center, St. Louis, MO, USA.
Although amyloid b immunotherapies offer great potential for prevention or delay of symptoms in dominantly inherited AD (DIAD), the mechanism of action of this class of medications does not address the underlying mechanism of most DIAD mutations. Moreover, the need for repeated IV infusions or sub-cutaneous injections with Ab immunotherapies may prove challenging for long-term prevention approaches. The majority of DIAD mutations appear to affect the interaction of the gamma-secretase enzyme with the Amyloid Precursor Protein (APP) making this enzyme an attractive target for disease modification.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Washington State University, Pullman, WA, USA.
Background: To promote caregiver health and reduce burden, the Savvy Caregiver Program (SCP), an evidence-based caregiving intervention, was adapted with a Native Hawaiian (NH) community in Hawai'i. The adaptation process occurred prior to pilot testing in two phases: 1) the preliminary adaptation by a community action board (CAB) and mentorship team and 2) pre-pilot testing and expert validation with NH adults. The preliminary adaptation, titled 'Auamo Kuleana O Nā Ma'i Poina ('Auamo Kuleana), aimed to include Hawaiian values, language, proverbs, and culturally relevant examples while maintaining the core components of the program.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University Hospital Cologne, Cologne, Germany.
Background: Value-based healthcare (VBHC) is a novel concept derived from economic research which is recently implemented in various medical departments and facilities. Additionally to an improvement of patient care, it postulates a reduction of expenses by providing patients with what they really need. Value in this context is defined as outcomes achieved for patients relative to the required costs.
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