AI Article Synopsis
- The manuscript presents a new, validated method for measuring ondansetron (OND) in various forms, including human plasma and dosage forms, using fluorescence.
- The study is the first to report OND fluorescence in a Triton X 100 solution, optimizing key variables for accurate results.
- The method demonstrates a linear response for OND concentrations from 0.2 to 2 μg/mL and has been used to study OND degradation under various conditions in accordance with ICH guidelines.
Article Abstract
The current manuscript describes a validated, responsive and rapid spectrofluorimetric method for quantifying ondansetron (OND) in authentic form, spiked human plasma and dosage forms. This is the first reported fluorescence study of Ondansetron in Triton X 100 system. Various variables affecting fluorescence response were studied precisely and optimised. The described method involved the fluorescence measurement in Triton X 100 system at λ/λ 354/317 nm. The calibration plot attained linearity over concentration range of 0.2 - 2 μg/mL. The developed method has been extensively applied to degradation studies of OND as per International Conference on Harmonisation (ICH) guidelines by exposing to oxidative, thermal, photo, acidic and alkaline conditions and also the degradation pathway has been proposed.
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