We introduce a decision model that interprets the relative levels of moment-by-moment spiking activity from the right and left superior colliculus to distinguish relevant from irrelevant stimulus events. The model explains detection performance in a covert attention task, both in intact animals and when performance is perturbed by causal manipulations. This provides a specific example of how midbrain activity could support perceptual judgments during attention tasks.
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http://dx.doi.org/10.1038/s41593-018-0271-5 | DOI Listing |
Alzheimers Dement
December 2024
Brain and Cognitive Sciences, Cell Science Research Center, Royan Institute for Stem Cell Biology & Technology, ACECR, Tehran, NY, Iran (Islamic Republic of).
Background: Alzheimer's disease (AD) is a degenerative condition characterized by a progressive decline in cognitive function, predominantly affecting older individuals. AD is associated with a range of histopathological alterations, including the gradual demise of neuronal cells, the accumulation of amyloid plaques, and the formation of neurofibrillary tangles. Furthermore, research suggests that the brain tissue of AD patients is subject to oxidative stress, which manifests as the oxidation of proteins, lipids, DNA, and the process of glycoxidation, throughout the disease progression.
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December 2024
The Medical University of South Carolina, Charleston, SC, USA.
Background: Alzheimer's disease disproportionately affects women in the U.S., with two-thirds of individuals diagnosed being female.
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December 2024
Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Background: Progressive supranuclear palsy (PSP) is the most common primary tauopathy, with a constellation of pathological features including 4R-tau positive neurofibrillary tangles and tufted astrocytes. Most PSP cases are sporadic and associated with common structural variation in the 17q21.31 MAPT locus as well as other loci, including EIF2AK3 which is critical for the integrated stress response (ISR).
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December 2024
Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands, Maastricht, Netherlands; Gordon Center for Medical Imaging, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Background: The brainstem locus coeruleus (LC) is among the first sites of Alzheimer's disease (AD) pathology, accruing hyperphosphorylated tau as early as in young adulthood. Animal studies indicate that the LC is crucially involved in sleep-wake regulation, a recently established factor contributing to AD-related pathophysiological processes. However, the associations between LC integrity and sleep-wake phenotypes in the context of AD pathology remain poorly characterized in humans.
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December 2024
University of California, San Diego, La Jolla, CA, USA.
Background: Pathological changes of Alzheimer's disease (AD) occur in the locus coeruleus (LC) years before clinical symptoms. This may affect LC activity that can be indexed by changes in pupil dilation. AD also disrupts connections between related but functionally distinct cortical areas leading to visual feature binding deficits.
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