Glutamate signaling regulates neuronal activity and synaptic plasticity, which underlies learning and memory. In this issue of , Foster found that metabotropic glutamate receptors mediate long-term potentiation in hippocampal neurons by mobilizing acidic endolysosomal Ca stores through the intracellular messenger NAADP.
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| http://dx.doi.org/10.1126/scisignal.aau3342 | DOI Listing |
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