Objective: The aim of this study was to compare pulmonary function tests (PFTs) among control subjects and patients with chronic rhinosinusitis (CRS) and to investigate the outcomes of endoscopic sinus surgery (ESS) on PFTs among patients with CRS.
Study Design: Prospective study conducted from June 2015 to June 2016.
Setting: Tertiary referral hospital.
Subjects And Methods: The study is based on 2 groups: adult control subjects (group 1, n = 25) and adult patients with medically resistant CRS (group 2, n = 25). PFTs were used to compare the lower airway condition between the groups. Another comparison in PFTs was made among patients with CRS at 1 week preoperatively and 1 month postoperatively to evaluate the effectiveness of ESS.
Results: In group 1, all subjects had an FEV1/FVC ratio ≥80% (forced expiratory volume in 1 second / forced vital capacity) with a mean of 0.84 ± 0.07, as compared with group 2, from 61% to 70% for 5 (20%) patients, 71% to 79% for 10 (40%), and ≥80% for 10 (40%). FEV1/FVC was significantly lower in group 2 than group 1 ( = .04). At 1 month postoperatively, the FEV1/FVC values of group 2 was from 61% to 70% for 2 (8%) patients, 71% to 79% for 13 (52%), and ≥80% for 10 (40%). The mean FEV1/FVC was 0.9 ± 0.50, and these values were significantly higher ( = .02) when compared with preoperative values.
Conclusion: This study provides objective evidence that patients with CRS may have nonmanifest lower airway affection when compared with control subjects and that ESS is efficacious in the improvement of such affection.
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http://dx.doi.org/10.1177/2473974X17738759 | DOI Listing |
World J Pediatr
January 2025
The First Hospital of Peking University, Beijing, China.
Background: Glucose transporter 1 deficiency syndrome (Glut1DS) was initially reported by De Vivo and colleagues in 1991. This disease arises from mutations in the SLC2A1 and presents with a broad clinical spectrum. It is a treatable neuro-metabolic condition, where prompt diagnosis and initiation of ketogenic dietary therapy can markedly enhance the prognosis.
View Article and Find Full Text PDFEndocr Connect
January 2025
Y Giwercman, Translational Medicine, Lund University, Malmö, Sweden.
Background: Prostate cancer therapy with surgical or chemical castration with GnRH agonists has been linked to elevated FSH levels, which may contribute to secondary health disorders, including atherosclerosis and diabetes. Although recent findings suggest a role for FSH beyond the reproductive system, its metabolic impact remains unclear and difficult to disentangle from that of androgens. In this study, we examined the metabolic changes induced by FSH and distinguished them from those caused by testosterone.
View Article and Find Full Text PDFJ Clin Sleep Med
December 2024
Department of Medical Sciences and Public Health, Sleep Disorder Research Center, University of Cagliari, Cagliari, Italy.
Study Objectives: Sleep disorders and/or disordered sleep represent common clinical presentations of pediatric acute-onset neuropsychiatric syndrome (PANS), occurring in up to 80% of affected children, with REM sleep motor disinhibition being a prevalent feature. To date, limited polysomnographic (PSG) studies have been conducted. Therefore, the objective of this study was to evaluate the PSG characteristics of a cohort of children with PANS, focusing particularly on REM sleep without atonia (RSWA) as assessed by the REM atonia index (RAI), and to compare these characteristics with those of a control group.
View Article and Find Full Text PDFEur Ann Allergy Clin Immunol
January 2025
Department of Allergy and Clinical Immunology, New Civil Hospital of Guadalajara "Dr. Juan I. Menchaca", Colonia La Perla, Guadalajara, Jalisco, México.
It has been observed that diseases such as rhinitis and asthma not only affect the physical health of individuals but can also significantly impact their psychological well-being. The aim of this study is to analyze the relationship between allergic rhinitis (AR), non-allergic rhinitis (NAR), and asthma with symptoms of depression in adults. Comparative cross-sectional study.
View Article and Find Full Text PDFJ Clin Invest
January 2025
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Single-cell transcriptomics applied to cerebrospinal fluid (CSF) for elucidating the pathophysiology of neurologic diseases has produced only a preliminary characterization of CSF immune cells. CSF derives from and borders central nervous system (CNS) tissue, allowing for comprehensive accounting of cell types along with their relative abundance and immunologic profiles relevant to CNS diseases. Using integration techniques applied to publicly available datasets in combination with our own studies, we generated a compendium with 139 subjects encompassing 135 CSF and 58 blood samples.
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