AI Article Synopsis
- The human genome project and advancements in genomic technologies have spurred significant interest in long noncoding RNAs (lncRNAs), which are non-protein-coding RNA molecules longer than 200 nucleotides.
- Increasing evidence suggests that lncRNAs play important roles in human growth, development, and the onset of diseases, particularly in the differentiation and activation of immune cells relevant to autoimmune diseases.
- This review highlights various lncRNAs associated with autoimmune diseases, emphasizing their potential applications as biomarkers and therapeutic targets in clinical settings.
Article Abstract
With the completion of the human genome project and further development of high-throughput genomic technologies, interest in long noncoding RNAs (lncRNAs), which are defined as non-protein-coding RNAs at least 200 nucleotides in length, has strongly increased, and lncRNAs have become a major research direction. Increasing evidence demonstrates that lncRNAs are closely related to human growth and development and to disease occurrence via various mechanisms. lncRNAs also play crucial roles in the differentiation and activation of immune cells, and their relationships with human autoimmune diseases have received increasing attention. The development of biotechnology has led to the gradual discovery of many potential lncRNA functions. In this review, we discuss various lncRNAs that have been implicated in different human autoimmune diseases, focusing on their clinical applications as potential biomarkers and therapeutic targets in the pathologies of diverse human autoimmune diseases. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 468-475, 2019.
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