AI Article Synopsis
- The study evaluated the effectiveness of montelukast in alleviating symptoms and improving patient-reported outcomes in individuals with nonallergic rhinitis eosinophilic syndrome (NARES).
- Eighty symptomatic patients were treated with 10 mg of montelukast daily for two months, with significant improvements noted in nasal and ocular symptoms, as well as reductions in eosinophilic biomarkers.
- Results showed that 42 out of 78 patients responded positively to the treatment, indicating that those with asthma had a higher likelihood of benefiting from montelukast therapy.
Article Abstract
Objective: The aim of our study was to analyze the montelukast effectiveness in improving oculonasal symptoms, patient-reported outcomes (PROs), and eosinophilic biomarkers in patients with nonallergic rhinitis eosinophilic syndrome (NARES).
Methods: We enrolled prospectively 80 symptomatic patients treated with 10 mg once a day of montelukast in monotherapy for 2 months. All patients were investigated before and after treatment. Nasal symptoms (nasal obstruction, rhinorrhoea, sneezing, nasal itching), ocular symptoms (redness/puffiness, watery eyes), and other PROs (olfactory dysfunction, difficulty going to sleep, nighttime awakenings, and nasal congestion on awakening) were scored by visual analogic scale. The following clinical scores were assessed: Total Nasal Symptom Score (T4NSS), Total Ocular Symptom Score (T2OSS), Total Symptom Score of Patient-Reported Outcomes (TSS-PROs), and a Composite Symptoms Score (CSS). Patients were classified as responders when a reduction of at least 50% of the CSS was observed. Before and after treatment, the eosinophilic biomarkers in nasal lavage were analyzed: nasal eosinophilia (number of eosinophils per high power field), eotaxin-1 and eotaxin-2.
Results: After treatment, significant reductions were observed for all the symptom scores. Forty-two of 78 patients were considered responders. A significant reduction of eosinophils in nasal mucosa and of levels of eotaxin-1 and eotaxin-2 in nasal lavage were observed after treatment in responder patients. Patients with asthma had an increased probability to be responders.
Conclusion: NARES patients may benefit from treatment with montelukast. In particular, the presence of concomitant asthma may be predictive of a greater efficacy.
Level Of Evidence: 2 Laryngoscope, 129:551-557, 2019.
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| http://dx.doi.org/10.1002/lary.27576 | DOI Listing |
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