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Lifetime stressors relate to invisible symptoms of multiple sclerosis.
Explor Neuroprotective Ther
April 2024
School of Nursing, University of Michigan, Ann Arbor, MI 48109, USA.
Aim: Childhood stressors can increase adult stress perception and may accumulate over the lifespan to impact symptoms of multiple sclerosis (MS). Growing evidence links childhood stressors (e.g.
View Article and Find Full Text PDFDemographic features, clinical characteristics, and comorbid relation in hidradenitis suppurativa: a population-based study.
Front Med (Lausanne)
January 2025
Department of Dermatology, Biruni University, İstanbul, Türkiye.
Background/objective: Hidradenitis suppurativa (HS) is a chronic inflammatory disease affecting apocrine gland areas, characterized by painful nodules and abscesses that may result in sinus tracts and scarring. The global prevalence of HS is increasing due to heightened awareness, improved diagnostic methods, rising obesity rates, and higher smoking prevalence. This study aimed to describe the epidemiological, clinical, and comorbid characteristics of HS patients.
View Article and Find Full Text PDFPivotal role of virulence genes in pathogenicity and vaccine development.
Front Med (Lausanne)
January 2025
Department of Veterinary Preventive Medicine, College of Veterinary Medicine, Qassim University, Buraydah, Saudi Arabia.
One of the most prevalent human infections is (), which affects more than half of the global population. Although infections are widespread, only a minority of individuals develop severe gastroduodenal disorders. The global resistance of to antibiotics has reached concerning levels, significantly impacting the effectiveness of treatment.
View Article and Find Full Text PDFBridging animal models and humans: neuroimaging as intermediate phenotypes linking genetic or stress factors to anhedonia.
BMC Med
January 2025
Early Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, 264 Guangzhou Street, Nanjing, China.
Background: Intermediate phenotypes, such as characteristic neuroimaging patterns, offer unique insights into the genetic and stress-related underpinnings of neuropsychiatric disorders like depression. This study aimed to identify neuroimaging intermediate phenotypes associated with depression, bridging etiological factors to behavioral manifestations and connecting insights from animal models to diverse clinical populations.
Methods: We analyzed datasets from both rodents and humans.
Prevalence of obsessive-compulsive symptoms in patients with schizophrenia treated with clozapine: a scoping review.
BMC Psychiatry
January 2025
Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru.
Background: Schizophrenia is a complex psychiatric disorder, and in patients treated with clozapine, it may induce or exacerbate obsessive-compulsive symptoms (OCS), which negatively affect patients' quality of life, functionality and treatment adherence. Despite its clinical relevance, the reported prevalence and characteristics of clozapine associated OCS vary widely, limiting effective management.
Objective: This scoping review synthesizes evidence on the prevalence of OCS in patients with schizophrenia treated with clozapine and explores treatment characteristics (types, severity, dose, and time to onset/exacerbation).
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