AI Article Synopsis
- Recent reports uncover new insights into how RNA polymerase II (Pol II) regulates gene transcription.
- A histidine-rich domain (HRD) facilitates transcription elongation through phase separation.
- A phosphatase switch plays a crucial role in initiating transcription termination.
Article Abstract
A few recent reports reveal fundamental new insights into the intricate regulatory mechanisms that govern RNA polymerase II (Pol II)-mediated gene transcription. Whereas a histidine-rich domain (HRD) triggers phase separation, promoting transcription elongation, a phosphatase switch promotes transcription termination. A paradigm that might govern the underlying mechanisms leading to robust gene transcription is now starting to emerge.
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| http://dx.doi.org/10.1016/j.tig.2018.11.002 | DOI Listing |
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