Background: Rational and appropriate use of blood and blood products is important in a resource limited setting like South Africa. Proper education is required in decision-making and management with regard to blood transfusion. Status of the current knowledge of blood transfusion practice is also necessary in order to identify target areas of teaching and patient management.
Objective: To assess the knowledge regarding blood and blood products among doctors of varying ranks at the University of the Witwatersrand affiliated academic hospitals.
Research Design And Methods: This is an observational, descriptive study using a self-administered questionnaire, comprising of 40 questions, equally divided into 6 sections covering different areas of transfusion medicine. Demographics of the participants and an opinion on how to impart further information was also included.
Results: A response rate of 33% was obtained from the distributed questionnaires. After grouping medical professionals together, an average score of 61% was obtained. As individual groups, the consultants achieved the highest score of 64%, while the interns, who averaged 56%, achieved the lowest score. The medical officers and registrars averaged 63%, while community service doctors averaged 58%. Participants scored the best in the section pertaining to 'consent' averaging 87%. This was followed by 64%, achieved for the section regarding 'adverse effects'. The section regarding 'red blood cell usage' and 'blood product ordering' was scored at 60%, while the section on 'platelet usage' attained a score of 44%. The lowest score was achieved in the section regarding 'plasma product usage', 30%. A statistically significant gap in knowledge (p = 0.0139) was noted from intern up to medical officer level, after which the increase in knowledge up to consultant level was not found to be statistically significantly different.
Conclusions: The overall results obtained appear to be suboptimal and can be improved upon. Formalized and on-going teaching around blood and blood product usage is required at both undergraduate and postgraduate levels, to ensure that this scarce, but invaluable resource is used judiciously and appropriately.
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http://dx.doi.org/10.1016/j.transci.2018.11.002 | DOI Listing |
Paediatr Drugs
January 2025
Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China.
Background: This study aimed to provide a comprehensive review of adverse events (AEs) associated with factor Xa (FXa) inhibitors in pediatric patients.
Methods: We searched PubMed, Embase, Cochrane Library, ClinicalTrials.gov, and the European Union Clinical Trials Register for English-language records from the establishment of the database up to October 17, 2023.
Biol Trace Elem Res
January 2025
Hebei Key Laboratory of Reproductive Medicine, Hebei Reproductive Health Hospital, Shijiazhuang 050071, Hebei, China.
Male infertility is a common complication of diabetes. Diabetes leads to the decrease of zinc (Zn) content, which is a necessary trace element to maintain the normal structure and function of reproductive organs and spermatogenesis. The purpose of this study was to investigate the effect of metformin combined with zinc on testis and sperm in diabetic mice.
View Article and Find Full Text PDFCurr Cardiol Rep
January 2025
Section of Pediatric Nephrology, Department of Pediatrics, Yale University School of Medicine, New Haven, USA.
Purpose Of Review: To review the benefits of ambulatory blood pressure monitoring and home blood pressure monitoring in children and to discuss implementation of guideline-recommended ambulatory blood pressure monitoring.
Recent Findings: Compared with office blood pressure, ambulatory blood pressure monitoring and home blood pressure monitoring provide superior accuracy, reproducibility, and stronger associations with target organ damage although future work is needed to determine the utility of home blood pressure monitoring to predict hypertension status on ambulatory blood pressure monitoring. Due to the benefits of out-of-office blood pressure measurement, ambulatory blood pressure monitoring has been recommended to confirm the diagnosis of hypertension in children and adolescents since publication of the 2017 American Academy of Pediatrics clinical practice guidelines on hypertension.
Metab Brain Dis
January 2025
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752, Porto Alegre, CEP 90610-000, RS, Brazil.
Phenylketonuria is a genetic disorder characterized by high phenylalanine levels, the main toxic metabolite of the disease. Hyperphenylalaninemia can cause neurological impairment. In order to avoid this symptomatology, patients typically follow a phenylalanine-free diet supplemented with a synthetic formula that provides essential amino acids, including L-carnitine.
View Article and Find Full Text PDFClin Rheumatol
January 2025
Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou Province, China.
Objective: Rheumatoid arthritis (RA) is an autoimmune condition that causes severe joint deformities and impaired functionality, affecting the well-being and daily life of individuals. Consequently, there is a pressing demand for identifying viable therapeutic targets for treating RA. This study aimed to explore the molecular mechanisms of osteoclast differentiation in PBMC from patients with RA through transcriptome sequencing and bioinformatics analysis.
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