Background: Reducing cadmium (Cd) exposure in Cd-polluted areas in Asia is urgently needed given the toxic effects of Cd. The short-term and long-term benefits of lowering Cd exposure are unknown because of its long half-life in the body.
Objectives: We aimed to investigate whether an intervention with low-Cd rice in a contaminated area of China reduced urinary Cd (UCd) levels and improved blood pressure and kidney function outcomes compared to no-intervention in consumers of high-Cd rice in the same region.
Methods: 106 non-smoking subjects were divided into three treatment groups: the intervention group (replacing homegrown high-Cd rice with market low-Cd rice, n = 34), the non-intervention group (continue eating high-Cd rice, n = 36) and the control group (continued eating low-Cd rice they have been eating for years, n = 36). The intervention period lasted for almost 8 months, during which participants were visited on up to 4 occasions and UCd, systolic and diastolic blood pressure (SBP, DBP), kidney function biomarkers (β-microglobulin and N-acetyl-β-D-glucosaminidase) were measured.
Results: After 3 months, the geometric mean UCd in the intervention (Int) group decreased significantly by 0.32 μg/g (p = 0.007), while changes were not significant in the non-intervention (non-Int) group (0.13 μg/g, p = 0.95) or the control group (-0.01 μg/g, p = 0.52). UCd in the Int group remained lower than in the non-Int group but higher than in the Control group through the end of follow up. DBP in the Int group decreased significantly from 80 mm Hg at month three (p = 0.03) and stayed around 74 mm Hg for the remainder of the study. SBP also decreased in the Int group but with variations similar to those observed in the other two groups. The two kidney biomarkers showed variations without a clear pattern.
Conclusion: This study suggested that UCd reflected both short-term (<3 months) and long-term Cd exposure. In addition, the low-Cd rice intervention showed initial benefits in lowering blood pressure levels, especially DBP, but not kidney biomarkers.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368677 | PMC |
| http://dx.doi.org/10.1016/j.envint.2018.11.019 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploration of cognitive flexibility and emotion recognition in adolescents with eating disorders.
J Int Neuropsychol Soc
January 2025
Department of Psychiatry, Ankara University, Ankara, Turkey.
Objectives: This study compared cognitive flexibility (CF) and emotion recognition (ER) in adolescents with eating disorders (ED) to a healthy group.
Methods: Forty healthy individuals aged 12-18 years with no psychiatric diagnosis and 46 patients diagnosed with anorexia nervosa (AN), bulimia nervosa (BN), or binge eating disorder (BED) according to DSM-5 criteria participated. CF was assessed using the Cognitive Flexibility Scale (CFS), Stroop Test, and Berg Card Sorting Test (BCST), while ER was evaluated using the test of perception of affect via nonverbal cues.
Utilization of Chlorella vulgaris methyl ester blend with diethyl ether to mitigate emissions of an unaltered single cylinder ci engine.
Environ Sci Pollut Res Int
January 2025
Engine Testing Laboratory, Department of Automobile Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, 603203, Tamil Nadu, India.
The present work emphasizes the viability of methyl ester production, characterization, and utilization of third-generation biofuel from Chlorella vulgaris microalgae. The presence of methyl oleate (CHO) in the Chlorella vulgaris methyl ester (CVME) algae signifies the existence of higher oxidation stability and prone to peroxidation. The single-stage transesterified CVME algae contains majorly (C-H) functional group trailed by (C = O), (C-O), (O-CH), (C-O-C) with the elemental compositions of 66.
View Article and Find Full Text PDFAssociation of digital eye strain with central corneal thickness: a cross-sectional observational pilot study.
Int Ophthalmol
January 2025
Department of Ophthalmology, Command Hospital, Pune, 411040, India.
Purpose: This study aimed to evaluate whether the digital eye strain (DES) was associated with the low central corneal thickness (CCT).
Methods: This observational cross-sectional pilot study was conducted from April 2023 to October 2023 at a tertiary eye care centre in North India, where CCT values were compared between subjects with DES and those without DES. Two hundred and eighty subjects (n = 280) aged 15-40 years with clear corneas and lenses were initially included in this study.
Effect of inferior oblique anterior transposition on vertical deviation.
Int Ophthalmol
January 2025
Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, Jilin, China.
Purpose: To evaluate the efficacy and complications of simplified graded inferior oblique anterior transposition (IOAT) in treating at least 10 PD vertical deviation in the primary position and inferior oblique muscle overaction (IOOA).
Methods: This retrospective study reviewed the medical records of 65 patients treated with simplified graded IOAT procedures for both vertical deviation and IOOA. Patients were grouped according to vertical deviation in the primary position.
SMILE for correction of myopia in patients during the incipient phase of presbyopia.
Int Ophthalmol
January 2025
Department of Ophthalmology, Peking University Third Hospital, No 49 Huayuan North Road, Haidian District, Beijing, 100191, China.
Purpose: To evaluate clinical outcomes and visual quality 12 months after small incision lenticule extraction (SMILE) for correction of myopia with or without astigmatism in patients during the incipient phase of presbyopia.
Setting: Peking University Third Hospital, Beijing, China.
Design: Retrospective observation study.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!