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Multiple-Dose Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Subcutaneous Rusfertide, a Hepcidin Mimetic, in Healthy Subjects.
Clin Pharmacol Drug Dev
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Protagonist Therapeutics, Inc., Newark, CA, USA.
Rusfertide, a peptide hepcidin mimetic, has shown efficacy in polycythemia vera. This trial investigated the multiple-dose pharmacokinetics, pharmacodynamics, and safety of once-weekly rusfertide 60 mg for 5 weeks in healthy subjects. Subjects were randomized to subcutaneous injection in the abdomen, upper arm, or thigh.
View Article and Find Full Text PDFImplicit neural representation-based method for metal-induced beam hardening artifact reduction in X-ray CT imaging.
Med Phys
January 2025
National Institute for Mathematical Sciences, Daejeon, Republic of Korea.
Background: In X-ray computed tomography (CT), metal-induced beam hardening artifacts arise from the complex interactions between polychromatic X-ray beams and metallic objects, leading to degraded image quality and impeding accurate diagnosis. A previously proposed metal-induced beam hardening correction (MBHC) method provides a theoretical framework for addressing nonlinear artifacts through mathematical analysis, with its effectiveness demonstrated by numerical simulations and phantom experiments. However, in practical applications, this method relies on precise segmentation of highly attenuating materials and parameter estimations, which limit its ability to fully correct artifacts caused by the intricate interactions between metals and other dense materials, such as bone or teeth.
View Article and Find Full Text PDFTransfer of the Oral Gonadotropin-Releasing Hormone Receptor Antagonist Relugolix Into Breast Milk of Healthy Lactating Women.
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Sumitomo Pharma Switzerland GmbH, Basel, Switzerland.
Relugolix is an oral gonadotropin-releasing hormone receptor antagonist that suppresses sex steroid hormones and is approved as monotherapy for prostate cancer and as a fixed-dose combination with estradiol/norethindrone for the treatment of endometriosis and uterine fibroids. The aim of this postmarketing study was to determine the pharmacokinetics and quantify the amount of relugolix excreted into breast milk of healthy lactating women. Following a single, oral dose of 40 mg relugolix, breast milk was sampled over 120 h.
View Article and Find Full Text PDFAdvancing microfluidic design with machine learning: a Bayesian optimization approach.
Lab Chip
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University of Novi Sad, BioSense Institute, Dr Zorana Djindjica 1, 21000 Novi Sad, Serbia.
Microfluidic technology, which involves the manipulation of fluids in microchannels, faces challenges in channel design and performance optimization due to its complex, multi-parameter nature. Traditional design and optimization approaches usually rely on time-consuming numerical simulations, or on trial-and-error methods, which entail high costs associated with experimental evaluations. Additionally, commonly used optimization methods require many numerical simulations, and to avoid excessive computation time, they approximate simulation results with faster surrogate models.
View Article and Find Full Text PDFTheory-Directed Ligand-Shell Engineering of Ultrasmall Gold Clusters: Remarkable Effects of Ligand Arrangement on Optical Properties.
J Phys Chem Lett
January 2025
Graduate School of Environmental Science, Hokkaido University, North 10 West 5, Sapporo 060-0810, Japan.
Ligand-shell engineering of ultrasmall metal clusters is a burgeoning research field aiming to develop cluster-specific properties. However, predicting these properties prior to synthesis is challenging due to their high sensitivity to geometric and/or electronic variations in ultrasmall metal cores, hindering further exploration. In this study, we present a theory-directed ligand-shell design and significant red-shift in absorption of a prolate-shaped [Au(diphosphine)Cl] cluster by synthesizing and characterizing enantiopure octagold clusters bearing chiral BINAP-type ligands [BINAP = 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl].
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