AI Article Synopsis
- The paper presents a direct pre-bonding technology that eliminates post-misalignment issues during chip manufacturing by integrating an alignment system with a microscope, vacuum, and alignment devices.
- A unique alignment method using microchannels and nanochannels allows for efficient alignment and assembly of micro/nanofluidic chips at a low cost and with quick production times.
- Ion enrichment experiments show the developed chips achieve a fluorescein concentration of roughly 5 μM, with an impressive 500-fold enrichment factor, confirming the device's effectiveness compared to other systems.
Article Abstract
In this paper, a direct pre-bonding technology after alignment of the chip is presented to avoid the post-misalignment problem caused by the transferring process from an alignment platform to a heating oven. An alignment system with a high integration level including a microscope device, a vacuum device, and an alignment device is investigated. To align the chip, a method of 'fixing a chip with microchannels and moving a chip with nanochannels' is adopted based on the alignment system. With the alignment system and the assembly method, the micro/nanofluidic chip was manufactured with little time and low cost. Furthermore, to verify the performance of the chip and then confirm the practicability of the device, an ion enrichment experiment is carried out. The results demonstrate that the concentration of fluorescein isothiocyanate (FITC) reaches an enrichment value of around 5 μM and the highest enrichment factor is about 500-fold. Compared with other devices, an alignment system presented in this paper has the advantages of direct pre-bonding and high integration level.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316881 | PMC |
| http://dx.doi.org/10.3390/mi9120621 | DOI Listing |
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