Tuberculosis of Thyroid gland is a rare entity even in countries with high prevalence of tuberculosis. The patients present with a broad spectrum of manifestations ranging from an isolated painful nodule to frank hyperthyroidism. We report an interesting case of primary tubercular granulomatous thyroiditis, presenting as a thyroid nodule with pyrexia of unknown origin, hyperthyroidism and severe anaemia which responded to anti tubercular and anti-inflammatory treatment with complete recovery, as evidenced by blood reports and CT scan reports. Thus, proper diagnosis may avoid unnecessary surgical interventions, that were a trend in the past.
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J Clin Med
January 2025
Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
: The nuclear factor (NF)-kB essential modulator (NEMO) has a crucial role in the NFκB pathway. Hypomorphic pathogenic variants cause ectodermal dysplasia with immunodeficiency (EDA-ID) in affected males. However, heterozygous amorphic variants could be responsible for Incontinentia Pigmenti (IP) in female carriers.
View Article and Find Full Text PDFInt J Surg Case Rep
January 2025
Department of Pediatric Surgery, Mohamed VI University Hospital, Faculty of Medicine and Pharmacy, Abdelmalek Essaâdi University, Tetouan, Morocco.
Introduction: Tuberculosis remains a major public health problem in developing countries. Isolated splenic tuberculosis is a rare form of extrapulmonary tuberculosis, with few cases documented in the literature, occurring mainly in immunocompromised individuals. The purpose of this article is to contribute to the medical knowledge regarding this rare disease and to highlight the diagnostic challenges and management approach.
View Article and Find Full Text PDFJMIR Res Protoc
December 2024
Department of Community Medicine, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Karnataka, Manipal, 576 104, India.
Background: Differentiating between tuberculosis and malignancy as the cause of an exudative lymphocyte predominant pleural effusion is difficult due to similarities in the cellular and biochemical characteristics of the pleural fluid in both conditions. Microbiological tests in tubercular pleural effusions have a poor diagnostic yield, and the long turnaround time for results prevents an early diagnosis. The diagnosis of malignant pleural effusion (MPE) is hampered by a variable yield of pleural fluid cytology and closed pleural biopsy and the fact that thoracoscopy may not be readily available or feasible in each patient.
View Article and Find Full Text PDFWorld J Nucl Med
December 2024
Department of Nuclear Medicine, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
Pituitary adenoma is the most common disease that affects the gland and may be classified as functional/nonsecretory tumors. Inflammatory/infective causes may also affect the pituitary gland. The 18F-fluorodeoxyglucose positron emission tomography/computed tomography (F18-FDG PET/CT) may have an incremental value in assessing these lesions and in determining their clinical significance.
View Article and Find Full Text PDFPLoS One
November 2024
Division of Infectious Diseases, Department of General Medicine, Amrita Institute of Medical Science and Research Centre, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
Tuberculosis (TB) remains a significant public health challenge in Low- and Middle-Income Countries (LMIC). Inappropriate use of Anti-Tubercular Treatment (ATT) undermines treatment efficacy and could contribute to drug resistance. While antimicrobial stewardship programs (AMSP) are well established, anti-tubercular treatment stewardship programs (ATTSP) in private hospitals do not have an established model.
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