AI Article Synopsis
- The study aimed to assess the presence of anti-thyroid antibodies in rheumatoid arthritis (RA) patients in south India and explore their clinical implications.
- Researchers conducted a cross-sectional study with 1217 patients suffering from fever and thrombocytopenia, and specifically focused on a case-control analysis involving 103 RA patients and 36 healthy controls to compare thyroid autoantibody levels and various clinical markers.
- Key findings revealed a significant correlation between anti-TTG antibodies and RA, along with notably elevated levels of anti-TPO antibodies in the RA group compared to controls.
Article Abstract
Aim: To evaluate the prevalence of anti-thyroid antibodies in a cohort of rheumatoid arthritis (RA) patients from south India and their clinical use.
Methods: A cross-sectional epidemiological study was conducted including 1217 patients aged more than 14 years with fever and thrombocytopenia admitted in the medical wards from October 2013 to September 2014. Detailed clinical examination and routine investigations were done; specific investigations like blood culture, widal test, antigen test for malaria, IgM ELISA leptospira, IgM ELISA dengue, bone marrow aspiration/biopsy etc. were done as and when indicated. The data are presented as percentage and numbers. Rates and ratios are computedThe prospective case-control study, conducted for 3 consecutive months in a tertiary care hospital based in India, evaluated 103 RA patients (active group) and 36 age-matched healthy controls without the disease. Both the control and active groups were compared for thyroid autoantibodies, and the clinical evaluation included assessment of swollen joint counts (SJC), tender joint counts (TJC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), pain scale, disease activity score (DAS), rheumatoid factor (RF), anti-nuclear antibody (ANA) and anti-cyclic citrullinated peptide (anti-CCP). The active group subjects were further subdivided into RA patients with and without hypothyroidism, and were compared for normal and abnormal levels of thyroid autoantibodies and the variations were statistically analysed.
Results: The corresponding mean age of the subjects belonging to the active and control groups were 47.09±11.29 and 41.03±11, with a female to male ratio of 1:0.12 and 1:0.29 respectively. Among the various thyroid autoantibodies compared between the active and control groups, a significant correlation (P=0.00936) was observed for anti-TTG antibodies. Also, the study has noted a significantly elevated level of anti-TPO antibodies in RA patients with hypothyroidism compared to the group without hypothyroidism (P=0.0074).
Conclusion: A significantly increased level of anti-TPO antibodies was noted in RA patients with hypothyroidism.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Quantification of Citrullinated Histone H3 as a Marker for Neutrophil Extracellular Traps Correlated to Clinical Characteristics of Patients with Systemic Lupus Erythematosus.
Arch Immunol Ther Exp (Warsz)
January 2025
Department of Human Physiology, Medical University of Lublin, Lublin, Poland.
Systemic lupus erythematosus (SLE) is an autoimmune disease whose pathogenesis is not fully understood to date. One of the suggested mechanisms for its development is NETosis, which involves the release of a specific network consisting of chromatin, proteins, and enzymes from neutrophils, stimulating the immune system. One of its markers is citrullinated histone H3 (H3Cit).
View Article and Find Full Text PDFProfile and Usefulness of Serum Cytokines to Predict Prognosis in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.
Neurol Neuroimmunol Neuroinflamm
March 2025
Hospices Civils de Lyon, Service de Neurologie, Sclérose en Plaques, Pathologies de la Myéline et Neuro-Inflammation-Hôpital Neurologique Pierre Wertheimer, Bron Cedex.
Objectives: To characterize the serum cytokine profile in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) at onset and during follow-up and assess their utility for predicting relapses and disability.
Methods: This retrospective multicentric cohort study included patients aged 16 years and older meeting MOGAD 2023 criteria, with serum samples collected at baseline (≤3 months from disease onset) and follow-up (≥6 months from the baseline), and age-matched and time to sampling-matched patients with multiple sclerosis (MS). Eleven cytokines were assessed using the ELLA system.
Anterior uveitis, pigmentary retinopathy, and pars plana exudates in Celiac disease.
Retin Cases Brief Rep
December 2024
Department of Histopathology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Purpose: To report a case of bilateral anterior uveitis, pigmentary retinopathy, and pars plana exudates in a patient with Celiac disease with complete resolution of inflammation following gluten-free diet.
Methods: Retrospective case report.
Results: A 19-year-old Asian Indian girl presented with bilateral non-granulomatous anterior uveitis for the past 2 months.
Molecular scalpels dissect new GluN1 hot spots in anti-NMDA receptor encephalitis.
Sci Immunol
January 2025
IDIBAPS Biomedical Research Institute, Barcelona, Spain.
Patient-derived NMDAR mAbs combined with single-particle cryo-electron microscopy reveal multiple GluN1 epitopes and distinct functional effects.
View Article and Find Full Text PDFLarge-scale multicenter study reveals anticitrullinated SR-A peptide antibody as a biomarker and exacerbator for rheumatoid arthritis.
Sci Adv
January 2025
Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China.
Current diagnosis and treatment of rheumatoid arthritis (RA) is still challenging. More than one-third of patients with RA could not be accurately diagnosed because of lacking biomarkers. Our recent study reported that scavenger receptor-A (SR-A) is a biomarker for RA, especially for anticyclic citrullinated peptide antibody (anti-CCP)-negative RA.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!